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تعداد نتایج: 17313466 فیلتر نتایج به سال:
Tomoyo Morita, Hiroki C. Tanabe, Akihiro T. Sasaki, Koji Shimada, Ryusuke Kakigi, and Norihiro Sadato Department of Integrative Physiology, Department of Cerebral Research, National Institute for Physiological Sciences, 38, Nishigo-Naka, Myodaiji, Okazaki, Aichi 444-8585, Japan, Graduate School of Environmental Studies, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan, Dep...
Although it is increasingly evident that cancer is influenced by signals emanating from tumor stroma, little is known regarding how changes in stromal gene expression affect epithelial tumor progression. We used laser capture microdissection to compare gene expression profiles of tumor stroma from 53 primary breast tumors and derived signatures strongly associated with clinical outcome. We pres...
Takashi Matsuzaka1,2, Hitoshi Shimano1,2, Naoya Yahagi2,3, Toyonori Kato1, Ayaka Atsumi1, Takashi Yamamoto1, Noriyuki Inoue1, Mayumi Ishikawa1, Sumiyo Okada1, Naomi Ishigaki1, Hitoshi Iwasaki1, Yuko Iwasaki1, Tadayoshi Karasawa1, Shin Kumadaki1, Toshiyuki Matsui1, Motohiro Sekiya3, Ken Ohashi3, Alyssa H Hasty4, Yoshimi Nakagawa1,2, Akimitsu Takahashi1, Hiroaki Suzuki1, Sigeru Yatoh1, Hirohito S...
htp:// D ow nladed from The tumor suppressor PTEN restrains cell migration and invasion by a mechanism that is independent of inhibition of the PI3K pathway and decreased activation of the kinase AKT. PREX2, a widely distributed GEF that activates the GTPase RAC1, binds to and inhibits PTEN. We used mouse embryonic fibroblasts and breast cancer cell lines to show that PTEN suppresses cell migra...
The DNA methyltransferase Dnmt1 maintains DNA methylation patterns and genomic stability in several in vitro cell systems. Ablation of Dnmt1 in mouse embryos causes death at the postgastrulation stage; however, the functions of Dnmt1 and DNA methylation in organogenesis remain unclear. Here, we report that Dnmt1 is crucial during perinatal intestinal development. Loss of Dnmt1 in intervillus pr...
During the formation of repetitive ectodermally derived organs such as mammary glands, lateral line and teeth, the tissue primordium iteratively initiates new structures. In the case of successional molar development, new teeth appear sequentially in the posterior region of the jaw from Sox2 cells in association with the posterior aspect of a pre-existing tooth. The sequence of molar developmen...
D ow lo The extent to which the contents of short-term memory are consciously accessible is a fundamental question of cognitive science. In audition, short-term memory is often studied via the mismatch negativity (MMN), a changerelated component of the auditory evoked response that is elicited by violations of otherwise regular stimulus sequences. The prevailing functional view of the MMN is th...
During embryonic development, the paraxial mesoderm becomes segmented into somites, within which proliferative muscle progenitors and muscle fibers establish the skeletal musculature. Here, we demonstrate that a gene network previously implicated in somite boundary formation, involving the transcriptional regulators Tbx6, Mesp-b and Ripply1, also confers spatial and temporal regulation to skele...
Mutant Traits Using a Controlled Vocabulary Kenji Akiyama, Atsushi Kurotani, Kei Iida, Takashi Kuromori, Kazuo Shinozaki and Tetsuya Sakurai* RIKEN Center for Sustainable Resource Science, Yokohama, Kanagawa, 230-0045 Japan Graduate School of Medicine, Kyoto University, Kyoto, Kyoto, 606-8501 Japan *Corresponding author: E-mail, [email protected]; Fax, +81-45-503-9665. (Received Septembe...
Lipid droplets (LDs) are ubiquitous organelles that store triacylglycerol and sterol esters for use by cells to produce energy and membranes (Martin and Parton, 2006; Walther and Farese, 2012). LDs emerge from the ER (Kassan et al., 2013; Pol et al., 2014), and their number, size, and distribution vary under different growth conditions (Yang et al., 2012). LDs are capable of interacting with ma...
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