BACKGROUND Natural products represent an important source for agents of cancer prevention and cancer treatment. More than 60% of conventional anticancer drugs are derived from natural sources, particularly from plant-derived materials. In this study, 2α, 3α, 19β, 23β-tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid from the leaves of Sinojackia sarcocarpa, was isolated, and its ant...

The autonomous mammotropie tumors (3I tT) studied have retained responsiveness to estrogen. Optimal growth of such tumors occurs at doses one-tenth tha t necessary to induce tumorous proliferation of mammotropie cells (Sit) in p i tu i ta ry glands in situ or in grafts or normal t)i tuitary tissue beneath the kidney capsule. The similari ty in sensitivity between normal 3 I t in situ and M:t in...

Recent genetic studies on the immune response suggest tha t idiotypic markers of antibodies are inherited. Id io typic cross-reactions were detected among the antibodies to the Group C carbohydra te from related rabbi ts while these same idiotypic specificities were not seen in unrela ted rabbi ts (1). Genetic studies with inbred mice immunized with various bacterial and synthet ic antigens ind...

BACKGROUND Little is known about the impact of the reason for revision total hip arthroplasty (THA) on the outcomes following revision THA. In this study, our objective was to assess the association of operative diagnosis with patient-reported outcomes (PROs) after revision THA. METHODS We used prospectively collected data from the Mayo Clinic Total Joint Registry that collects pre- and post-...

CONTEXT Although prevalence of obesity and incidence of total joint arthroplasty (TJA) have dramatically increased over the last two decades in the U.S., little is known of the preoperative and postoperative weight patterns of patients undergoing TJA. OBJECTIVE To describe the preoperative and postoperative weight patterns of patients undergoing TJA and evaluate characteristics associated wit...

W h e n analyzing the probabil ist ic per formance of an a lgor i thm one usually considers this a lgor i thm w.r.t , an infinite family of probabi l i ty spaces of inputs. In case of satisfiability a lgor i thms for proposi t ional formulas main ly two types of families of input spaces are considered: One is the constant density model dealt with for example in [6] the other one is the constant...

Tranexamic acid (TXA) reduces red blood cell transfusion in various orthopedic surgeries, yet the degree of practice variation its use among anesthesiologists and surgeons has not been described. To target future knowledge transfer implementation strategies, to better understand determinants variability prophylactic TXA use, our primary objective was evaluate influence surgical team members on ...

BACKGROUND To address the long-term problems of bearing surface wear and osteolysis associated with conventional metal-polyethylene (M-PE) total hip arthroplasty (THA), metal-metal (M-M), and ceramic-ceramic (C-C) bearings have been introduced. These bearing surfaces are associated with unique risks and benefits and higher costs. However the relative risks of these three bearings in an older po...

Total hip arthroplasty (THA) in patients with high hip dislocation is challenging and technically demanding. Nerve injury is a problem associated with leg lengthening after THA. The purpose of this study was to identify the risk factors for sciatic nerve injury after THA in patients with high hip dislocation. Thirty-seven patients (41 THAs) with Crowe type IV hips were consecutively treated. Th...