نتایج جستجو برای: 105
تعداد نتایج: 30068 فیلتر نتایج به سال:
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Vitamin D receptor (VDR) agonists (VDRAs) are commonly used to manage hyperparathyroidism secondary to chronic kidney disease (CKD). Patients with CKD experience extremely high risks of cardiovascular morbidity and mortality. Clinical observations show that VDRA therapy may be associated with cardio-renal protective and survival benefits in patients with CKD. The 5/6 nephrectomized (NX) Sprague...
PURPOSE We have synthesized a new tubulin ligand N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide (IG-105). This work investigates its anticancer effect and mechanism. EXPERIMENTAL DESIGN Anticancer efficacy was evaluated at the molecular target, cancer cells and nude mice. The mechanism was explored at submolecular, molecular, and cellular levels. RESULTS IG-105 showed a pote...
OBJECTIVE The serial peaks of vestibular-evoked myogenic potentials (VEMPs) have been labeled p13, n23, n34 and p44 according to their latency. Waves p13-n23 have been shown to be of saccular origin, whereas the origin of waves n34-p44 is still unknown. In order to improve the clinical applicability of waves n34-p44, we examine the use of different patterns of acoustic stimuli to evoke constant...
Melanoma is the skin tumor with highest morbidity and mortality highly variable incidence rates that depend mainly on genetic-population, geographical behavioral factors 1. In our country we do not have a specialized, unified vast oncology registry system allows us to evaluate historical behavior of neoplasms (incidence, prevalence mortality) actions as health professionals. Previous informatio...
BACKGROUND Glutathione-S-transferases (GST) regulate the cellular response to oxidative stress. We previously highlighted the importance of oxidative stress in taxane toxicity and therefore investigated the relationship between the GST isoforms M1, T1 and P1 gene polymorphisms and docetaxel (Taxotere)-induced peripheral neuropathy (DIPN). PATIENTS AND METHODS The GSTM1 (null), GSTT1 (null) an...
We performed a postmarketing surveillance study to determine the efficacy and safety of the oral quinolone antibacterial agent garenoxacin (Geninax(®) Tablets 200 mg) against atypical pneumonia. Between October 2009 and July 2011, patients with community-acquired pneumonia visited 26 facilities in Japan; we collected survey forms from 105 of these patients who were suspected of having atypical ...
In this present study the population dynamics of the soil bacteria of some coastal villages, namely Padima, Jatimati, Chanpabani, Palsandapur, Bhagibaharampur, Duttapur, Gangadharpur, Gobindabasan, Somaibasan of Digha, West Bengal, India, was determined. In these villages the aerobic heterotrophic, Gram-negative, spore-forming, starch-hydrolyzing, Pseudomonas, nitrate-reducing, denitrifying, as...
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