We performed a positron emission tomography study, using regional cerebral blood ̄ow as the index of brain activity, to address the speci®city of brain activation pattern by acupuncture stimulation of short duration at the classical analgesic point. Needling manipulation at 2 Hz was performed at a classical point of prominent analgesic ef®cacy (Li 4, Heku) and a near-by non-classical/non-analge...

We investigated the distribution of calcium/calmodulin-dependent protein kinase II (CaM kinase II) in the brains of mice infected with ME7 scrapie strain. CaM kinase II is an enzyme that plays a major role in the regulation of long-term potentiation, a form of synaptic plasticity associated with learning and memory. Immunoreactivity of CaM kinase II a, measured by Western blot, increased marked...

We analyzed the aplolipoprotein E (APOE) genotypes of 110 probable AD patients and 226 cognitively normal controls in Koreans. The APOE 14 allele was more prevalent in both earlyand late-onset AD patients (P , 0:01) than in controls. The odds for the APOE 14-heterozygous subjects were 2.7 (95% CI ˆ 1:6±4:5), and those for the APOE 14-homozygous subjects were 17.4 (95% CI ˆ 2:0±147:3). But the o...

Fitts' law states that the movement time (MT) of an aiming movement is a linear function of the index of dif®culty (ID), where IDˆ log2(2A/W), A is the movement amplitude, and W is the target width. This law implies that MT should remain unchanged as long as A/W remains constant (i.e. the absence of a scaling effect). The goal of this study was to investigate whether, during upright posture, re...

We demonstrate a CW random distributed feedback Raman fiber laser operating in a 1.2 μm spectral band. The laser generates up to 3.8 W of the quasi-CW radiation at 1175 nm with the narrow spectrum of 1 nm. Conversion efficiency reaches 60%. Up to 1 W is generated at the second Stokes wavelength of 1242 nm. It is shown that the generation spectrum of RDFB Raman fiber laser is much narrower than ...

Recently, Glass and Krisch have extended the Vaidya radiating metric to include both a radiation fluid and a string fluid (1999 Class. Quantum Grav. 16 1175). Mass diffusion in the extended Schwarzschild atmosphere was studied. The continuous solutions of classical diffusive transport are believed to describe the envelope of the underlying fractal behaviour. In this work we examine the classica...

Conflict of interest: None declared. References 1 Cornfield J, Haenszel W, Hammond EC, Lilienfeld AM, Shimkin MB, Wynder EL. Smoking and lung cancer: recent evidence and a discussion of some principles. J Natl Cancer Inst 1959;22:173–204. Reprinted Int J Epidemiol 2009;38:1175–91. 2 Cochran WG. The planning of observational studies of human populations (with discussion). J R Stat Soc A 1965;128...