Aim: Deficiency of cobalamin and folate during pregnancy is associated with megaloblastic anemia. Lower levels of folate and vitamin B12 were reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid (MMA) levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate d...

By S. J. BAKER, V. I. MATHAN AND K. ABE H YPERPIGMENTATION OF THE SKIN in Indian patients with megaloblastic anemia appears to have been first documented by Cook.1 Studies from this unit suggested that this was often associated with vitamin B12 deficiency,2’3 though more recent studies following the introduction of folic acid assays, have shown that it can also occur in some cases of pure folat...

OBJECTIVE To determine the prevalence and possible factors associated with anaemia, and vitamin B12 and folate deficiencies in women of reproductive age (WRA) in Pakistan. METHODS A secondary analysis was conducted on data collected through the large-scale National Nutrition Survey in Pakistan in 2011. Anaemia was defined as haemoglobin levels <12 g/dL, vitamin B12 deficiency as serum vitamin...

Serum vitamin B,2 levels of 2523 individuals were measured using the hemoglobin-coated charcoal assay. In one hespital, the test was performed on 1698 patients under hematologic evaluation for erythrocytic abnormalities of all types, while 825 patients from five other hospitals were studied because of suspected B,2 deficiency. The incidence of low serum vitamin B,2 was surprisingly low for both...

Thrombocytopenia is the reduction of platelet number to below normal level. It may be due to the decrease in production, increase in destruction, abnormal spreading in the body or the laboratory errors. B12 deficiency is a rarely seen vitamin deficiency in childhood. It presents with megaloblastic anemia and is difficult to diagnose because of various clinical findings. Here we would like to pr...

Alterations in reticulocyte size occur 2-3 days after the onset of iron deficient or megaloblastic erythropoiesis and precede, by several weeks, changes in mean corpuscular volume (MCV). Iron-deficiency anemia induced in a normal subject by repeated phlebotomies was characterized by the initial development of larger than normal reticulocytes followed by an abrupt decrease in reticulocyte size. ...

Writ/i the technical assistance of Miss Lila Fliegelnian O CCASIONAL REPORTS have presemited cytogenetic data from cases of megaloblastic anemia.ii,uul Although no consistemit cytogenetic abnormalities have yet beeii found, a variety of changes have been described in some cases of pernicious anemia.m’ ’m” The significance of these findings is not clear. This report describes cytogenetic observa...

Background: Vitamin B-12 deficiency is usually accompanied by elevated concentrations of serum total homocysteine (tHcy) and methylmalonic acid (MMA). Folate deficiency also results in elevated tHcy. Measurement of these metabolites can be used to screen for functional vitamin B-12 or folate deficiency. Objective: We assessed the prevalence of vitamin B-12 and folate deficiency in a population-...

Deficiency of vitamin D3 has become common in both developed and developing countries. Vitamin D receptors are found on the granulosa cells ovarian tissue its deficiency plays a role dysfunction. Anti Mullerian Hormone (AMH) is generated small growing follicles ovaries by cells. Serum AMH one marker for reserve. We reviewed current literature present clinical practice. There relationship betwee...