Long-term administration of 9-amino-1,2,3,4-tetrahydroacridine (THA) has been reported to produce marked clinical improvement in patients suffering from Alzheimer's disease. The dramatic enhancement of cognitive function seen with THA contrasts sharply with the modest improvements seen with other forms of anticholinesterase therapy, suggesting that additional mechanisms might play a role in its...

The increasing demand for total hip arthroplasty (THA) in relatively young, high-demand patients has led to the use of hard-on-hard bearing surfaces. Adverse local tissue reaction/pseudotumor and elevated serum metal ion levels are commonly reported complications encountered in metal-on-metal THA, while audible articulation and rim fracture are reported in ceramic-on-ceramic THA. For this reaso...

Intraoperative fracture rates in total hip arthroplasty (THA) have been associated with uncemented stems, anterolateral surgical approach, diagnoses other than osteoarthritis, and female gender. The purpose of this study was to investigate if changes in stem design would influence intraoperative fracture rates. 1497 THA with Bi-Metric stems were compared to 1277 THA with Echo Bi-Metric Full Pro...

BACKGROUND Compared to the posterior approach, the anterior approach to total hip arthroplasty (THA) offers the potential for an accelerated recovery secondary to less dissection and therefore less pain in the immediate postoperative period. This offers potential financial benefit through a reduction in length of stay. This study retrospectively reviewed 98 anterior approach and 69 posterior ap...

Dr David Hamilton (http://www.nzma.org.nz/journal/118-1227/1774) accurately describes the clinical benefits of temozolomide and PHARMAC’s consideration of funding; and how this relates to what price to pay to prolong survival in incurable illnesses. We update progress with the funding of temozolomide, and agree there are dilemmas around the funding of high-cost medicines that give definite if l...

Metal-metal total hip arthroplasty (THA) is contraindicated in patients with impaired renal function due to increased metal ion output relative to other bearings and renal excretion of metal ions. Although one can avoid a metal-metal THA in a patient with renal disease, a patient may be destined to develop renal disease later in life. In this study, we sought to determine the incidence of newly...

Ochronosis is a rare autosomal recessive disorder of tyrosine metabolism characterized by multilevel spinal degeneration and arthritis large weight-bearing joints, which referred to as ochronotic arthropathy. In this case report, we describe diagnosis treatment arthropathy in patient who underwent total hip arthroplasty (THA) knee (TKA). The Harris score was 26 preoperatively 45, 68, 76, 90, 92...

1Computer Science Department, University of Geneva, Battelle Campus, 7 Route de Drize, 1227 Carouge (Geneva), Switzerland 2Computer Science Department, University of Applied Studies (HES-SO), 4 Rue de la Prairie, 1202 Geneva, Switzerland 3Center for Research and Technology Hellas (ITI/CERTH), Informatics and Telematics Institute, 1st Km Thermi-Panorama Road, P.O. Box 361, 57001 Thermi-Thessalon...

In this study, we report the purification, initial structural characterization, and functional analysis of the molecular chaperone ClpB from the gram-positive, halophilic lactic acid bacterium Tetragenococcus halophilus. A recombinant T. halophilus ClpB (ClpB(Tha)) was overexpressed in Escherichia coli and purified by affinity chromatography, hydroxyapatite chromatography, and gel filtration ch...

BACKGROUND Most patients with displaced femoral neck fractures are treated by THA and hemiarthroplasty, but it remains uncertain which if either is associated with better function and lower risks of complications. QUESTIONS/PURPOSES We performed a meta-analysis of randomized controlled trials (RCTs) to determine whether THA was associated with lower rates of reoperations, mortality, complicat...