نتایج جستجو برای: 125 imaging agents tissues distribution
تعداد نتایج: 1566781 فیلتر نتایج به سال:
The application of magnetic resonance imaging (MRI) to non-invasively assess disease biomarkers has been hampered by lack of desired contrast agents with high relaxivity, targeting capability, and optimized pharmacokinetics. We developed a novel MRI probe which targets HER2, a biomarker for various cancers and a target for anti-cancer therapies. This multimodal HER2-targeted MRI probe integrate...
Elastography is a new imaging modality where elastic tissue parameters related to the structural organization of normal and pathological tissues are imaged. Basic principles underlying the quasi-static elastography concept and principles are addressed. The rationale for elastographic imaging is reinforced using data on elastic properties of normal and abnormal soft tissues. The several orders o...
background: finding a suitable method for rapid, accurate and reliable estimation of absorbed dose has high priority in management of the radiation exposed persons. shortly after radiation exposure, apoptosis is a major detriment in proliferative tissues such as the hematopoietic system. therefore, quantification of apoptosis in these tissues could be useful for rapid estimation of radiation ex...
Stabilized microbubbles with a size between 1-5 µm are used as ultrasound contrast agents in the clinical routine. They have shown convincing results for the vascular characterization of tissues as well as in echocardiography. Due to their size, microbubbles strictly remain intravascular where they can be detected with high sensitivity and specificity. This qualifies them for intravascular mole...
The development of anticancer therapies that target the angiogenic process is an area of major growth in oncology. A method of noninvasively measuring tumor vascular endothelial growth factor (VEGF) in vivo could provide important efficacy information for VEGF-dependent antiangiogenic agents and the role of VEGF in cancer biology. We have developed a novel radiotracer for use with positron emis...
Although various clinical imaging modalities have been developed to visualize internal body structures and detect abnormal tissues prior to surgical procedures, most medical imaging modalities do not provide disease-specific images in real-time. Optical imaging can provide the surgeon with real-time visualization of the surgical field for intraoperative image-guided surgery. Imaging in the near...
Receptors for some regulatory peptides are highly expressed in tumors. Selective radiolabeled peptides can bind with high affinity and specificity to these receptors and exhibit favorable pharmacologic and pharmacokinetic properties, making them suitable agents for imaging or targeted therapy. The success encountered with radiolabeled somatostatin analogs is probably the first of a long list, a...
Radiolabeled benzamides are attractive candidates for targeted radiotherapy of metastatic melanoma as they bind melanin and exhibit high tumor uptake and retention. One such benzamide, N-(2-diethylamino-ethyl)-4-(4-fluoro-benzamido)-5-iodo-2-methoxy-benzamide (MIP-1145), was evaluated for its ability to distinguish melanin-expressing from amelanotic human melanoma cells, and to specifically loc...
Nanoparticles of silicates and germanates with a general formula Sr2R8–x–yErxYbyM6O26 (R = Y, La; M Si, Ge) were produced in vacuum by the method pulse electron beam evaporation. An upconversion photoluminescence nanoparticles was detected during excitation laser wavelength 980 nm predominance lines red near infrared regions spectrum. Due to their optical properties, can be excited directly thr...
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