The pathogenesis of vitiligo was examined for clues to the pigmentary changes that may occur after treatment with topical imiquimod. The literature varies on the pigmentary changes induced by topical use of imiquimod. The US Food and Drugs Administration lists 68 reports of pigmentary changes out of a total of 1257 reports related to imiquimod lodged from 1997 to 2003. Some studies describe vit...

Embryonic fibroblasts from S1P (sphingosine-1-phosphate) lyase-deficient mice [Sgpl1-/- MEFs (mouse embryonic fibroblasts)] are characterized by intracellular accumulation of S1P, elevated cytosolic [Ca2+]i and enhanced Ca2+ storage. Since S1P, produced by sphingosine kinase 2 in the nucleus of MCF-7 cells, inhibited HDACs (histone deacetylases) [Hait, Allegood, Maceyka, Strub, Harikumar, Singh...

Currently, electric taxis have been deployed in many cities of China. However, the charging unbalance in both temporal and spatial scale has become a rising problem, which leads to low charging efficiency or charging congestion in different stations or time periods. This paper presents a multi-objective coordinated charging strategy for electric taxis in the temporal and spatial scale. That is,...

OBJECTIVES We aimed to evaluate the validity of the self-reported smoking indicator used in the Global Youth Tobacco Survey (GYTS). SETTING 43 middle and high-school classrooms from 26 schools were selected from Mexico City and Cuernavaca, Morelos. PARTICIPANTS A total of 1257 students provided both a questionnaire and a urine sample. PRIMARY AND SECONDARY OUTCOME Sensitivity and specific...

OBJECTIVES To implement and assess a rules based computerised prescribing system with the aim of improving the safety of prescriptions and the administration of drugs. DESIGN Analysis of performance of computerised system plus questionnaire survey of users. SETTING 64 bed renal unit in a teaching hospital. INTERVENTION : Introduction of the system into routine clinical use. MAIN OUTCOME...

OBJECTIVE To examine the potential impact of deferral of blood donors at high risk of HIV infection in a west African city where blood is screened for HIV antibodies but no other special measures are taken to protect the blood supply. DESIGN Cross sectional study. SETTING National Blood Transfusion Centre and Project RETRO-CI, an international collaborative AIDS research project, Abidjan, C...

OBJECTIVE To examine the contribution of co-occurring nonhead injuries to hazard of death after traumatic brain injury (TBI). PARTICIPANTS A random sample of Olmsted County, Minnesota, residents with confirmed TBI from 1987 through 1999 was identified. DESIGN Each case was assigned an age- and sex-matched, non-TBI "regular control" from the population. For "special cases" with accompanying ...

750 required to kill the tumor while in the case of neutron rays only = 2.9 times the 260 mouse lethal dose produces the same tumor effect. This comparison of dosage ratios indicates that neutron rays may be more selective than x-rays in their effects on this tumor. We are indebted to Dr. Francis Carter Wood for specimens of Sarcoma 180, and to Dr. R. S. Stone for his interest and for the x-ray...

OBJECTIVE To compare the activity, efficacy and toxicity of docetaxel versus docetaxel plus cisplatin in patients with non-small-cell lung cancer. METHODS A literature search was performed in the EMBASE, Medline, Cochrane Library, Web of Science, China National Knowledge Internet, Wan-fang databases. The trials that were found were then evaluated for eligibility. The Cochrane Collaboration's ...

Roger Bacon is something of an enigma. He has been called many things – ‘Britain’s first scientist’, ‘wonderful doctor’, ‘conjurer’ and ‘magician’. Many of the details of his life are uncertain and they have been discussed and argued about by scholars for centuries. He is generally thought to have been born in Ilchester, Somerset, around 1214, although some authors have put his date of birth as...