1 2 3 4 5 Poliovirus infection transiently increases COPII vesicle budding 6 Meg Trahey, Hyung Suk Oh, Craig E. Cameron, and Jesse C. Hay 7 Division of Biological Sciences and Center for Structural and Functional Neurosceince, 8 The University of Montana, Missoula, MT 59812; Department of Biochemistry and 9 Molecular Biology, The Pennsylvania State University, University Park, PA 16802 10 11 *C...

To develop an inducible and progressive model of mammary gland tumorigenesis, transgenic mice were generated with a mouse mammary tumor virus-long terminal repeat-driven, conditional, fibroblast growth factor (FGF)-independent FGF receptor (FGFR)1 (iFGFR1) that can be induced to dimerize with the drug AP20187. Treatment of transgenic mice with AP20187 resulted in iFGFR1 tyrosine phosphorylation...

Background and Purpose: Formation of pseudohyphae is considered a virulence factor in Candida species. Generally, Candida glabrata grows as budding yeast cells; however, reports illustrated that C. glabrata could form pseudohyphal cells in response to some stimuli. In this study, we provided insight into the ability of C. glabrata in forming pseudohyphal cells under different levels of carbon d...

It is currently thought that all secretory proteins travel together to the Golgi apparatus where they are sorted to different destinations. However, the specific requirements for transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in yeast could be explained if protein sorting occurs earlier in the pathway. Using an in vitro assay that reconstitutes a single...

HIV-1 recruits cellular endosomal sorting complexes required for transport (ESCRTs) to bud virions from the membrane. Disruption of the viral nucleocapsid (NC) domain integrity affects HIV-1 budding. However, the molecular mechanisms of NC's involvement in HIV budding remain unclear. We find that NC mimics the PDZ domains of syntenin, a membrane-binding adaptor involved in cell-to-cell contact/...

The super-saturated surfactant monolayer collapses with the nanoparticles (NPs) at the water/trichloroethylene (TCE) interface are investigated using molecular dynamics (MD) simulations. The results show that sodium alkyl sulfate (SDS) monolayer collapse is initiated by buckling and followed primarily by budding and the bud encapsulating the NPs and oil molecules. The developed bud detaches fro...

a wide range of medicinal plant parts that possess varied medicinal properties are used for extracts as raw drugs. in this study, the ethanolic extract obtained from aerial parts of fennel (foeniculum vulgare mill.) seedlings was evaluated in vitro to examine their antimicrobial activity against four gram-negative and three gram-positive bacteria and two fungi. aerial parts of one-month-old see...

Enveloped viruses are released from infected cells after coalescence of viral components at cellular membranes and budding of membranes to release particles. For some negative-strand RNA viruses (e.g., vesicular stomatitis virus and Ebola virus), the viral matrix (M) protein contains all of the information needed for budding, since virus-like particles (VLPs) are efficiently released from cells...

Saccharomyces cerevisiae cells select bud sites according to one of two predetermined patterns. MATa and MAT alpha cells bud in an axial pattern, and MATa/alpha cells bud in a bipolar pattern. These budding patterns are thought to depend on the placement of spatial cues at specific sites in the cell cortex. Because cytoskeletal elements play a role in organizing the cytoplasm and establishing d...

background: oral lichen planus (olp) has been classified as a pre-malignant condition. matrix metalloproteinase-13 (mmp-13) or collagenase-3 may play a key role in cancer development. the aim of this study was to compare serum and saliva mmp-13 between patients with oral lichen planus (olp) and oral squamous cell carcinoma (oscc).   methods : this cross sectional study was performed on 30 patie...