The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detrimental long-term health effects in a cohort of 13 cloned sheep. We perform musculoskeletal assessments, metabolic tests and blood pressure measurem...

Paf-acether (paf) is a naturally occurring phospholipid involved in inflammatory processes. The presence of paf, its precursor lyso paf, and lipo-paf has been determined in blood and synovial fluid from 13 patients with rheumatoid arthritis (RA), 11 with spondylarthropathies, eight with other inflammatory rheumatisms, 13 with chondrocalcinosis, 15 with osteoarthritis, and also in blood from nin...

In the present study, the levels of synovial fluid biomarkers of patients with knee osteoarthritis (OA) and those with meniscus injury (MI) were compared to associate the levels of synovial fluid biomarkers with the degree of OA and MI. Synovial fluid samples were obtained from 51 cases with OA and 40 patients with MI. Severity of OA and MI were evaluated using the Kellgren-Lawrence (K-L) class...

Approximately 7000 rare disorders exist, affecting 2 percent of Canadians and millions of people worldwide. Given that for many rare diseases only one allele is mutated, we hypothesize inducing expression of the remaining wild-type allele may have a therapeutic effect. SMAD3 heterozygosity results in Aneurysms-Osteoarthritis Syndrome (AOS) – an aortic aneurysm disorder also known as Loeys-Dietz...

OBJECTIVES Obesity as measured by body mass index (BMI) is one of the major risk factors for osteoarthritis. In addition, genetic overlap has been reported between osteoarthritis and normal adult height variation. We investigated whether this relationship is due to a shared genetic aetiology on a genome-wide scale. METHODS We compared genetic association summary statistics (effect size, p val...

OBJECTIVE To measure the validity and reliability of the WOMAC, IKDC and Lysholm questionnaires among patients with knee osteoarthritis and determine the influence of age on their scores. METHOD Fifty-seven patients diagnosed with primary osteoarthritis of the knee answered the SF-36, WOMAC, IKDC and Lysholm questionnaires. Validity was tested by measuring the correlation (Pearson's correlati...

Background and Aim: Sagittal imbalance is often presented as one of the major problems in individuals suffering from orthopedic pain, particularly those affected by destructive hip joint osteoarthritis. In this regard, total arthroplasty (THA) a therapeutic procedure for such patients has resulted restoration sagittal balance. Therefore, present study aimed to evaluate changes balance using EOS...

Aims: Research has shown that most of the elderly suffer from knee osteoarthritis. Massage therapy is one of the non-pharmacological methods that according to studies can be used to relieve the symptoms caused by knee osteoarthritis in the elderly. Therefore, the present study was conducted with the aim of reaching a comprehensive view on massage therapy in relieving the symptoms of knee osteoa...

Osteoarthritis is a whole-joint disease characterized by the progressive destruction of articular cartilage involving abnormal communication between subchondral bone and cartilage. Our team previously identified 14-3-3ε protein as a subchondral bone soluble mediator altering cartilage homeostasis. The aim of this study was to investigate the involvement of CD13 (also known as aminopeptidase N, ...