The first Adaptive Hypermedia System (AHS) was presented in the early nineties (Furuta & Scotts, 1990), (Ginderen, 1990). However, this model was not based in World Wide Web (WWW). The first use in WWW appeared in 1996 (Brusilovsky, 1996). Currently, AHS are used for information recovery; interface adaptation, user assistance, learning support, dialogue, cooperation support and others applicati...

In mesial temporal lobe epilepsy (mTLE), the predominant form of epilepsy in adults, and in animal models of the disease, there is a conspicuous loss of the intracellular Ca(2+)-binding protein calbindin-D(28k) (CB) from granule cells (GCs) of the dentate gyrus. The role of this protein in nerve cell function is controversial, but here we provide evidence for its role in controlling Ca(2+) infl...

Ebola, considered till recently as a rare and endemic disease, has dramatically transformed into a potentially global humanitarian crisis. The genome of Ebola, a member of the Filoviridae family, encodes seven proteins. Based on the recently implemented software (PAGAL) for analyzing the hydrophobicity and amphipathicity properties of alpha helices (AH) in proteins, we characterize the helices ...

BACKGROUND Members of racial and ethnic minority groups are most likely to experience limited access and poor engagement in addiction treatment. Research has been limited on the role of program capacity and delivery of comprehensive care in improving access and retention among minorities with drug abuse issues. The goal of this study was to examine the extent to which access and retention are e...

The field of pharmacogenetics is witnessing a growing interest in the role of the human leukocyte antigen (HLA) in manifestation of adverse drug reactions (ADR). Here we report a retrospective analysis of the association of HLA-B*5701 with abacavir hypersensitivity syndrome (AHS) in a large Canadian cohort of 489 human immunodeficiency virus-1-positive patients exposed to abacavir. A total of 3...

Risks of non-cancer outcomes after exposure to atomic bomb (A-bomb) radiation have been evaluated among the Life Span Study (LSS) cohort and its subcohort, the Adult Health Study (AHS). Information regarding non-cancer outcomes in the LSS is obtained from death certificates. In the AHS, members undergo clinical examinations biennially to determine their health status. Many AHS studies have been...

Vegetarian dietary patterns have been reported to be associated with a number of favourable health outcomes in epidemiological studies, including the Adventist Health Study 2 (AHS-2). Such dietary patterns may vary and need further characterisation regarding foods consumed. The aims of the present study were to characterise and compare the food consumption patterns of several vegetarian and non...

Havacılık operasyonlarının sürdürülebilirliği için onaylı havacılık kuruluşlarında kalite yönetimi sisteminin kurulması gereklidir. Kalite yönetim sistemi, ilgili işletme yönetmeliklerine uygun ve kuruluşun stratejik hedeflerini başarmak yöneticisi tarafından yürütülmektedir. operasyonlarındaki hataların uçuş emniyet riskleri son derece önemli olmasından dolayı, yönetmeliklere insana dayalı ris...

Numerous proteins target lipid droplets (LDs) through amphipathic helices (AHs). It is generally assumed that AHs insert bulky hydrophobic residues in packing defects at the LD surface. However, this model does not explain targeting of perilipins, most abundant and specific LDs, which are weakly hydrophobic. A striking example Plin4, whose gigantic repetitive AH lacks residues. Using a range co...