In a eukaryotic cell, each messenger RNA (mRNA) is bound to a variety of proteins to form an mRNA-protein complex (mRNP). Together, these proteins impact nearly every step in the life cycle of an mRNA and are critical for the proper control of gene expression. In the cytoplasm, for instance, mRNPs affect mRNA translatability and stability and provide regulation of specific transcripts as well a...

1. Rodriguez EM, Staffa JA, Graham DJ. The role of databases in drug postmarketing surveillance. Pharmacoepidemiol Drug Saf. 2001;10(5):407-410. 2. Wysowski DK, Swartz L. Adverse drug event surveillance and drug withdrawals in the United States, 1969-2002: the importance of reporting suspected reactions. Arch Intern Med. 2005;165(12):1363-1369. 3. Moore TJ, Cohen MR, Furberg CD. Serious adverse...

Genomic data facilitate opportunities to track complex population histories of divergence and gene flow. We developed a metric, scaled block size (SBS), which uses the nonrecombined block size of introgressed regions of chromosomes to differentiate between recent and ancient types of admixture, and applied it to the reconstruction of admixture in cattle. Cattle are descendants of 2 independentl...

In this paper, we consider a composite difference-of-convex (DC) program, whose objective function is the sum of smooth convex with Lipschitz continuous gradient, proper closed and function, concave function. This problem has many applications in machine learning data science. The proximal DCA (pDCA), special case classical algorithm (DCA), as well two Nesterov-type extrapolated – ADCA (Phan et...

Apatite-type structure is known for its flexibility towards accommodating numerous ions of different crystallographic affinities. Two samples fluorellestadite from two pyrometamorphic rocks (slags) burned waste heaps (BWH) France (LdS) and Poland (RDT) were studied in terms their trace element composition using Laser Ablation Inductively Coupled Plasma Mass Spectrometry. Boron shows an evident,...

Scanning 3000 cases admitted for rehabilitation after cerebrovascular accident over a 20 year period produced a sample of 1369 subjects, without age restrictions, admitted within six months of a first stroke of thrombotic etiology. In this sample, survival rates showed no significant difference between men and women. Age at onset, however, clearly influenced survival changes; the expected mean ...

A goal of the Chromosome-centric Human Proteome Project is to identify all human protein species. With 3844 proteins annotated as "missing", this is challenging. Moreover, proteolytic processing generates new protein species with characteristic neo-N termini that are frequently accompanied by altered half-lives, function, interactions, and location. Enucleated and largely void of internal membr...