Diabetes mellitus is associated with increased infection rates. We studied clinical features and outcome of community-acquired bacterial meningitis in diabetes patients. Patients were selected from a nationwide, prospective cohort on community-acquired bacterial meningitis performed from March 2006 to October 2014. Data on patient history, symptoms and signs on admission, treatment, and outcome...

Cancer is the third major cause of death in the world and it has turned into an enormous threat to human health. MicroRNAs have been considered as novel and noninvasive biomarkers for human cancer detection. The microRNA-183 (miRNA-183, miR-183) family, consisting of miR-96, miR-182 and miR-183, is considered to be associated with various types of human cancer. However, the diagnostic performan...

(2002a, 183) distinguishes the following four putative uses or senses of 'knowledge': (1) Knowledge = belief (2) Knowledge = institutionalized belief (3) Knowledge = true belief (4) Knowledge = justified true belief (plus) 1 (1) and (2) he characterizes as " loose " uses or senses of 'knowledge'; by 'loose', he means " an extended, technical use that departs from the standard, colloquial senses...

Enhanced ganoderic acid Me (GA-Me, an important anti-tumor triterpene) yield was attained with the medicinal fungus Ganoderma lucidum using response surface methodology (RSM). Interactions were studied with three variables, viz. glucose, peptone and culture time using a Central Composite Design (CCD). The CCD contains a total of 20 experiments with the first 14 experiments organized in a fract...

miRNAs are largely known to base pair with the 3'UTR of target mRNAs, downregulating their stability and translation. mRNA of betaTrCP1 ubiquitin ligase is very unstable, but unlike the majority of mRNAs where 3'UTR determines the rate of mRNA turnover, betaTrCP1 mRNA contains cis-acting destabilizing elements within its coding region. Here we show that degradation of mRNA of betaTrCP1 is miRNA...