The earliest generative work derived all nominalizations syntactically (Chomsky 1955-6, Lees 1960). Chomsky (1970) then argued that only -ing gerunds are derived syntactically, while all other types of event nominals, such as refutation, acceptance, refusal, are derived morphologically in the lexicon from bases that are unspecified between nouns and verbs. The suffix -ing was shown to serve bot...

Anthelmintic resistance creates a major hitch over the decades throughout the world. As per WHO only few drugs are frequently used in the treatment of helminth infestations in human beings. In view of this, an attempt has been made to study the anthelmintic activity of some newly synthesized 1-substituted imidazoles (1a-1d, 2a-2d) were synthesized and characterized by their spectral data. All t...

A 48-year-old woman presented with dyspepsia, a 5-kg weight loss, and night sweating for 2 months. She had no underlying disease and denied alcohol consumption or smoking. Her vital signs, physical examination, and laboratory results were unremarkable. Abdominal computed tomography (CT) showed multiple low-density lesions of variable sizes in the spleen, with perisplenic lymph node enlargement ...

Usher syndrome (USH) is a clinically and genetically heterogeneous disorder characterized by congenital hearing loss combined with retinitis pigmentosa. This dual sensorineural deficiency is transmitted in an autosomal recessive mode. Usher syndrome type I (USH1) is the most severe form. Four loci responsible for USH1 (USH1A, 1B, 1C and 1D) have previously been mapped, among which only the USH1...

Colombo Scientifically Speaking continued on page 18 Figure 1. Full-length intracellular siRNA quantification protocol. (A) DSsiRNA was loaded into carriers and used for transfection of H1299-EGFP cells. (B) Total RNA was extracted and reverse transcribed (C) using stem-loop primers. Optimized RT conditions allowed for an efficient transcription of the AS. (D) The cDNA template was detected by ...

Antimicrobial activity in vitro of a series of novel azaphenothiazine derivatives containing a quinoline moiety was investigated using Gram-positive (Staphylococcus aureus, Enterococcus faecalis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) strains as well as in Candida albicans yeast. The examined compounds showed the highest activity against Enterococcus faecalis and Escherich...

T ranscatheter cardiovascular interventions are nowadays more frequently and safely performed, thus leading to populate the heart with medical devices. Here, we describe an unusual complication following percutaneous closure of a patent foramen ovale (PFO) with an atrial septal occluder. A 52-year-old woman with history of transient ischemic attack was found to have a PFO associated with an atr...

Amelogenesis imperfecta (AI) is a group of inherited conditions featuring isolated enamel malformations. About 5% of AI cases show an X-linked pattern of inheritance, which are caused by mutations in AMELX. In humans there are two, non-allelic amelogenin genes: AMELX (Xp22.3) and AMELY (Yp11.2). About 90% of amelogenin expression is from AMELX, which is nested within intron 1 of the gene encodi...

A 36-year-old man was referred to our hospital for a recent finding of a heart murmur. He had no relevant medical history except paroxysmal palpitations in the previous three months. Physical examination revealed a high-grade continuous rumbling murmur best heard at the left sternal border. Initial transthoracic echocardiography showed continuous flow between the aorta and the right ventricle (...

…hu†…n† ˆ u…n‡ 1† ‡ u…nÿ 1† ‡ V …n†u…n† …1:1D† on `2…Z† (and the half-line problem, h‡, on `2…fn 2 Zjn > 0g† `2…Z‡†) with u…0† ˆ 0 boundary conditions. We will also discuss the continuum analog …Hu†…x† ˆ ÿu00…x† ‡ V …x†u…x† …1:1C† on L2…R† (and its half-line problem, H‡, on L2…0;1† with u…0† ˆ 0 boundary conditions). We will focus on a new approach to the absolutely continuous spectrum rac…h† a...