New aromatic glycoconjugate building blocks based on the trifunctional 3-aminomethyl-5-aminobenzoic acid backbone and sugars linked to the backbone by a malonyl moiety were prepared via peptide coupling. The orthogonally protected glycoconjugates, bearing an acetyl-protected glycoside, were converted into their corresponding acids which are suitable building blocks for combinatorial glycopeptid...

In order to evaluate the role of such a system in the living leaf, a specific inhibitor of either Reaction 2 or 3 would be desirable. The relationship between sulfanilamide and the metabolism of p-aminobenzoic acid (4) suggested that cw-hydroxysulfonic acids by analogy might be effective inhibitors of the action of the enzymes concerned with the metabolism of cr-hydroxycarboxylic acids.2 The bi...

p-Aminobenzoic acid (pABA) plays important roles in a wide variety of metabolic processes. Herein we report the synthesis, theoretical calculations, crystallographic investigation, and in vitro determination of the biological activity and phytotoxicity of the pABA salt, 2-hydroxyethylammonium p-aminobenzoate (HEA-pABA). The ability of neutral and anionic forms of pABA to interact with TIR1 pock...

In order to evaluate the role of such a system in the living leaf, a specific inhibitor of either Reaction 2 or 3 would be desirable. The relationship between sulfanilamide and the metabolism of p-aminobenzoic acid (4) suggested that cw-hydroxysulfonic acids by analogy might be effective inhibitors of the action of the enzymes concerned with the metabolism of cr-hydroxycarboxylic acids.2 The bi...

Although p-aminobenzoylglutamic acid can be used as substrate in place of p-aminobenzoic acid to yield dihydrofolic acid directly, dihydropteroic acid is thought to be an intermediate (as shown above) rather than p-aminobenzoylglutamic acid, because paminobenzoic acid is utilized as substrate at least 10 times more effectively than p-aminobenzoylglutamic acid (2). The formulation of the dihydro...

The acetylation of p-aminobenzoic acid (PAB) (2) and of sulfanilamide (3) by the rat has been shown to depend upon an adequate supply of pantothenic acid, a constituent of the coenzyme A molecule (4). In addition the extent of acetylation is decreased by giving large amounts of PAB with reference to the size of the animal (5, 6) and to a smaller extent by a deficiency of riboflavin (5). The pre...

In order to evaluate the role of such a system in the living leaf, a specific inhibitor of either Reaction 2 or 3 would be desirable. The relationship between sulfanilamide and the metabolism of p-aminobenzoic acid (4) suggested that cw-hydroxysulfonic acids by analogy might be effective inhibitors of the action of the enzymes concerned with the metabolism of cr-hydroxycarboxylic acids.2 The bi...