Caspases are an extended family of cysteine proteases that play critical roles in apoptosis. Animals deficient in caspases-2 or -3, which share very similar tetrapeptide cleavage specificities, exhibit very different phenotypes, suggesting that the unique features of individual caspases may account for distinct regulation and specialized functions. Recent studies demonstrate that unique apoptot...

OBJECTIVE This study looks to compare the antidepressant efficacy and safety of a standardized extract of St John's wort with both placebo and fluoxetine. METHOD After a 1-week single-blind washout, patients with major depressive disorder diagnosed by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition were randomized to 12 weeks of double-b...

Gerald Tesauro IBM Watson Research Center PO Box 704 Yorktown Heights, NY 10598 The issues of scaling and generalization have emerged as key issues in current studies of supervised learning from examples in neural networks. Questions such as how many training patterns and training cycles are needed for a problem of a given size and difficulty, how to represent the inllUh and how to choose usefu...

The effects of somatostatin analogues RC-160 and SMS-201-995 on tyrosine phosphatase and cell proliferation were investigated in COS-7 and NIH 3T3 cells expressing human somatostatin receptor subtype 1 or 2 (SSTR1 or SSTR2). Binding experiments were performed on membranes from COS-7 cells expressing human SSTR1 or SSTR2 using 125I-labeled [Tyr11]S-14 or [Tyr3]SMS-201-995, respectively. The soma...

PURPOSE E-cadherin is a transmembrane glycoprotein with important roles in the maintenance of cervical squamous epithelium integrity. The purpose of this study was to investigate the relationship between E-cadherin-160 C/A polymorphism and cervical intraepithelial neoplasia (CIN). METHODS A case-control study was performed enrolling 70 CIN cases and 107 age-matched healthy controls. Each pati...

SEAL was rst introduced in 1] by Rogaway and Copper-smith as a fast software-oriented encryption algorithm. It is a pseu-dorandom function which stretches a short index into a much longer pseudorandom string under control of a secret key pre-processed into internal tables. In this paper we rst describe an attack of a simpliied version of SEAL, which provides large parts of the secret tables fro...