Methods We generated single nucleotide polymorphism (SNP) genotypes from the genomic DNA of 988 children with sJIA and 514 healthy control subjects. These data were combined with SNP genotypes in silico from 7370 additional healthy control subjects. After dividing the dataset into 9 strata by country of origin, we excluded samples and markers that did not meet our strict quality requirements. W...

Biotransformation of benzo[a]pyrene (BaP) in the presence of microsomal fractions derived from liver and epiderm of adult and weanling rats was examined. The aim of this study was to evaluate the effect of age on the capacity of two organs in transformation of BaP. Subcellular fractions were prepared from skin and liver by ultracentrifugation and were used as the source of BaP metabolizing enzy...

Prostate cancer (PCa) is one of the most common malignancies among men and is the second leading cause of cancer-associated mortality in the developed world. Androgen deprivation therapy (ADT) is the most common treatment for PCa. However, the majority of androgen-sensitive PCa patients will eventually develop resistance to ADT and the disease will become androgen-independent. There is, therefo...

(1) A neurone (designated cell 204) has been identified in the segmental ganglia of the leech which, when stimulated intracellularly in isolated nerve cords, reliably initiates and maintains the neuronal activity pattern characteristic of swimming. In a minimally dissected leech, cell 204 activity results in normal swimming movements. (2) Cell 204 is an unpaired, intersegmental interneurone whi...

OBJECTIVES/HYPOTHESIS Following endoscopic ventral skull base surgery (EVSBS), it is common practice to obtain early postoperative imaging. The role of postoperative computed tomography (CT) and magnetic resonance imaging (MRI) scans in these patients remains unclear. This study aims to determine the clinical utility of early postoperative imaging after EVSBS for detecting postoperative complic...

While structured packing modules are known to be efficient for surface wetting and gas-liquid exchange in abiotic surface catalysis, this model study explores structured packing as a growth surface for catalytic biofilms. Microbial biofilms have been proposed as selfimmobilized and self-regenerating catalysts for the production of chemicals. A concern is that the complex and dynamic nature of b...

We propose here to clarify some of the relations existing between information and meaning by showing how meaningful information can be generated by a system submitted to a constraint. We build up definitions and properties for meaningful information, a meaning generator system and the domain of efficiency of a meaning (to cover cases of meaningful information transmission). Basic notions of inf...

The identification of biomarkers in breast cancer diagnosis and therapy is important in achieving early cancer diagnosis and improving patient outcomes. The aim of this study was to examine clinical significance of miR-204 expression in tissues from breast cancer patients. The relationship between miR-204 expression and clinicopathological characteristics was investigated. MiR-204 expression wa...

MicroRNA-204 (miR-204) has been reported to be frequently downregulated in various types of cancer, including renal, brain, ovary, hematological and colon cancer. The present study, investigated the effects of miR‑204 on renal cell carcinoma. Following transfection of miR‑204, an MTT assay, cell migration assay, cell invasion assay, western blot analysis and luciferase assay were performed in r...