BACKGROUND The role of vascular endothelium in the control of epicardial coronary artery vasomotion during treadmill exercise remains unclear. Therefore, we examined the consequences of in vivo balloon endothelial denudation on external coronary diameter of the left circumflex artery during exercise in conscious dogs. METHODS AND RESULTS Seven dogs instrumented for the measurement of arterial...

Under proper conditions, whole blood can be stored at room temperature for as long as 21 days before measurement of glycosylated hemoglobin by affinity chromatography. Whole blood (anticoagulated with EDTA or heparin) was placed in capillary tubes, which were then sealed at both ends and stored at room temperature. Just before assay, whole blood was rinsed from the tubes and diluted 10-fold wit...

Forty neonate calves were used in this study. The animals were divided into two treatment (n = 20) andcontrol (n = 20) groups. In the treatment group, oral iron as ferrous sulphate was supplemented to each calf atthe dose of 150 mg/day for 28 days, from the birthday. Blood sampling was taken from jugular veinimmediately after birth and on days 7, 14, 21 and 28 after birth. Significant differenc...

This research aimed to investigate the protective effect of p-CA, a derivative phenolic acid, against toluene-induced oxidative damage. A total 32 Sprague-Dawley male rats, 8 in each group, were used. 4 groups formed as control, toluene, p-CA and toluene+p-CA. Animals control toluene group given 0.9 % NaCl, mg kg-1 b.w 100 orally for 21 days, respectively. The animals toluene+p-CA received 3 da...

Of 198 deermice (Peromyscus spp) collected from various localities in the southwestern United States and northern Mexico, 106 (54%) had eimerian oocysts in their feces when examined. These included 50 of 106 (47%) Peromyscus truei, 34 of 54 (63%) Peromyscus maniculatus, 4 of 17 (24%) Peromyscus leucopus, and 18 of 21 (86%) Peromyscus eremicus. The following Eimeria were identified from infected...

BACKGROUND Few studies have focused on peripheral nerve conduction during exposure to microgravity. The -6° head-down tilt (HDT) comprises an experimental model used to simulate the space flight environment. This study investigated nerve conduction characteristics of rhesus monkeys before and after prolonged exposure to HDT. METHODS Six rhesus monkeys (3-4 years old) were tilted backward 6° f...

Abstract INTRODUCTION In patients with newly-diagnosed glioblastoma, rapid early progression (REP) refers to tumour regrowth between surgery and postoperative chemoradiotherapy. This systematic review meta-analysis appraised published data on REP better characterise understand it. METHODS Systematic searches of MEDLINE, EMBASE the Cochrane database from inception 21/10/21. Studies describing in...

Article history: Received 24 March 2008 Received in revised form 6 August 2008 Accepted 8 August 2008 The objective of this study was to determine the effect of dietary inclusion of benzoic acid on utilization of the macrominerals Ca, P, Mg, K, Na, and Cl in growing pigs. Eighteen barrows, initial BW of 28±1.7 kg, were assigned to 3 diets: a basal diet based on barley, wheat, soybean meal, corn...

BACKGROUND There is pre-clinical evidence of synergism between cisplatin (P) and temozolomide (T) due to higher inhibition by T of O6-alkyl-guanine-alkyltransferase (AGAT), an enzyme involved in the mismatch repair system. T and P are active against malignant gliomas while thalidomide (TH) is emerging as an inhibitor of angiogenesis. PATIENTS AND METHODS Triplets of patients with malignant br...