∗Research (partially) supported by Hungarian National Foundation for Scientific Research, grant nos. K68398, K75016, FP7 IEF grant GEOSUMSETS. ∗∗Research (par-

Background Nivolumab 3 mg/kg every 2 weeks (Q2W) has shown benefit versus the standard of care in melanoma, non-small cell lung cancer (NSCLC), and renal cell carcinoma (RCC). However, flat dosing is expected to shorten preparation time and improve ease of administration. With knowledge of nivolumab safety, efficacy, and pharmacokinetics across a wide dose range in body weight (BW) dosing, asse...

Application development staffs that build and maintain mainframe application programs to manage business systems have a variety of specialized skills. An integrated development environment, like CA Ideal for CA Datacom, is needed to share storage of batch and online program logic providing version control, an integrated Data Dictionary and the ability to insulate the programmer from transaction...

CONTENTS 1. Introduction 230 2. Concepts of the functional role of striatal dOpaminergic activity 231 2.1. Introduction 231 2.2. The behavioural actions of dopamine in the striatum: unitary or diverse? 231 2.3. Regional differences in the striatal functions revealed by the actions of dopamine 232 2.4. The side to which the striatum's behavioural effects are referred 232 2.4.1. The traditional v...

The terminal web of the intestinal brush border contains a spectrin-like protein, TW 260/240 (Glenney, J. R., Jr., P. Glenney, M. Osborne, and K. Weber, 1982, Cell, 28:843-854.) that interconnects the "rootlet" ends of microvillar filament bundles in the terminal web (Hirokawa, N., R. E. Cheng, and M. Willard, 1983, Cell, 32:953-965; Glenney J. R., P. Glenney, and K. Weber, 1983, J. Cell Biol.,...

Angus, Hereford and Red Poll crossbred yearling heifers (n = 81) were mated to Brown Swiss bulls. Pregnant heifers were assigned on the bases of weight and breed cross to one of three diets and fed to achieve maternal weight gains of 0, .5 or 1.0 kg/d. Heifers from each treatment group were slaughtered at about 120, 150, 180, 210, 240, or 255 d postmating. Reproductive tracts were recovered at ...

Coral-derived calcium carbonate/hydroxyapatite macroporous constructs of the genus Goniopora with limited hydrothermal conversion to hydroxyapatite (7% HA/CC) initiate the induction of bone formation. Which are the molecular signals that initiate pattern formation and the induction of bone formation? To evaluate the role of released calcium ions and osteoclastogenesis, 7% HA/CC was pre-loaded w...

BACKGROUND Orthodontic treatment with fixed appliances requires - among others - the correct clinical expression of torque, which depends on the precise fitting of archwire and slot. Especially in the lingual technique torque problems become clinically more evident than in labial appliances also with respect to the vertical alignment of teeth due to different distances from the center of resist...

This document describes the surface realization solution submitted by UCM to the Surface Realization Challenge. The UCM submission operates over the shallow representation of the challenge input. This submission to the surface realization challenge relies on an old-fashioned surface realizer based on unification with a grammar. Because this surface realizer requires fully specified inputs, a co...

The size of a minimum realizer of a partial order is called the dimension of that partial order. Here we initiate the study of minimal realizers which are not minimum. As an aid to the study of such realizers, we associate to each minimal realizer certain critical digraphs. We characterize all such critical digraphs for the antichain on n elements, and consequently deduce that for n > 4, the ma...