The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self-renewing cancer stem cells are poorly understood. Here, we exploit T-cell acute lymphoblastic leukemia (T-ALL) as a model to define the critical initiating events in this disease. First, thymocytes that are reprogrammed by the SCL and LMO1 oncogenic transcription factors ...

OBJECTIVE Mental illness is prevalent among general hospital ward patients but often goes unrecognised. The aim of this study was to validate the SCL-8d as a brief questionnaire for mental disturbances for use in general hospitals. METHODS The study included 2040 patients, 18 years or older, consecutively admitted to 11 general internal medicine wards in seven European countries. All patients...

Abstract In our previous work, we have proved that the spatial coherence length (SCL) of the incident waves around the target together with the target configuration play a leading role in the determination of the enhancement in the radar cross-section (ERCS) of a target in a random medium. Owing to the double-passage effect, the ERCS is almost two when the SCL is much smaller or larger than the...

OBJECTIVE This study aimed to establish the sternal skin conductance level (SCL) increase that would optimally detect hot flashes among breast cancer patients. METHODS Fifty-six women who had completed a similar treatment protocol for a first diagnosis of breast cancer within the previous 3 months wore an ambulatory sternal skin conductance device for one home-based daytime recording of hot f...

Transcription factors, such as those of the basic-helix-loop-helix (bHLH) and homeodomain classes, are primary regulators of cell fate decisions and differentiation. It is considered axiomatic that they control their respective developmental programs via direct binding to cognate DNA sequences in critical targets genes. Here we test this widely held paradigm by in vivo functional assay of the l...

Screening of a strongly charged macroion by its multivalent counterions cannot be described in the framework of a mean-field Poisson-Boltzmann (PB) theory because multivalent counterions form a strongly correlated liquid (SCL) on the surface of the macroion. It was predicted that a distant counterion polarizes the SCL as if it were a metallic surface and creates an electrostatic image. The attr...

OBJECTIVE Standard treatment in hypoparathyroidism consists of calcium and vitamin D (or vitamin D analogs) but does not employ replacement of the actual missing hormone. Only few studies have evaluated the efficacy of calcium/vitamin D treatment in hypoparathyroidism; the impact of chronic hypoparathyroid disease on well-being has not been investigated previously. DESIGN Cross-sectional, con...

BACKGROUND High levels of stress and deteriorating mental health among medical students are commonly reported. In Bergen, Norway, we explored the impact of personality traits measured early in their curriculum on stress reactions and levels of depression and anxiety symptoms as junior physicians following graduation. METHODS Medical students (n = 201) from two classes participated in a study ...

We evaluated the potential clinical value of the Symptom Checklist-90-Revised (SCL-90-R) as a multidimensional self-report measure to identify the expected higher rates of clinically significant mental health symptoms in adults with partial/complex partial epilepsy (PE), as compared to a representative sample of adult non-patients. As expected, adults with PE had significantly higher rates of e...

SCL/tal is a putative oncogene originally identified through its involvement in the translocation t(1;14)(p32;qll) present in the leukemic cell line DU.528. Subsequent studies have shown an upstream deletion activating expression of SCLI tal to be one of the most common genetic lesions in T-cell acute lymphoblastic leukemia (T-ALL). The cDNA sequence of SCL/tal encodes a basic helix-loop-helix ...