Anticoagulation during extracorporeal circulation is achieved by a variety of protocols. 1 •2•3•4 ·5 Of those routinely used, the most convenient method of heparin management utilized the activated clotting time (ACT) and dose-response curve (DRC) as described by Bull.6 It has become apparent, however, that a number of factors other than heparin concentration influence the ACT. This study was d...

The one abnormality constantly found in hemophilia is an inability of the blood to coagulate in a normal manner. This defect is demonstrable usually by a prolonged clotting time, which in turn determines the various manifestations of the disease. Further understanding of this disease depends, therefore, upon knowledge of the cause of the prolonged clotting time. Most investigations of the blood...

That the role of thrombin in the conversion of fibrinogen to fibrin is essentially enzymatic, is established not only by the minute amounts of thrombin which are effective but also by the complete independence of fibrin yields and thrombin concentrations over a very wide range of thrombin dilutions and clotting times. The thrombin-fibrinogen reaction, in the phase beyond the "latent period" at ...

Ancient Greek philosophers extolled moderation in all things. On page 283, Minamoto and colleagues show that carbon monoxide (CO) inhalation is no exception. In a mouse model of trachea transplantation, inhaled CO—in moderation—prevented the development of lethal obstructive airway disease. CO gas is both a toxic air pollutant and a normal byproduct of cellular heme metabolism. Although CO is w...

Vitamins k is an important fat-soluble vitamin that can be obtained from plants, bacteria and animals necessary for the blood clotting. It plays a key function as cofactor in synthesizing of clotting proteins liver; recently, interest its functions extra-hepatic tissue has increased. Vitamin deficiency usually caused by abnormal absorption rather than lack food. Apart impact on clotting, chroni...

OBJECTIVES To study the effect of escitalopram and fluoxetine on coagulation profile in patients with major depression. METHOD This was a prospective, open-label, single-centre study in 40 patients diagnosed with major depressive disorder. The patients were diagnosed using Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria. Twenty patients receiving escitalopram 10...

Thrombus formation is critical in the pathogenesis of coronary artery disease, and faster clotting speed as measured by activated partial thromboplastin time (aPTT) has been associated with recurrent cardiovascular events in acute coronary syndrome (ACS) patients [2]. Only two small studies have investigated the association of PTSD with markers of coagulation. One case–control study (N = 14 PTS...

BACKGROUND Since October 2010, the combination of a heparin-grafted polyacrilonitrile (AN69ST) membrane with a 0.80 mmol/L citric acid-containing dialysate is routinely used in our centre for intermittent haemodialysis, without systemic anticoagulation, in critically ill patients with increased bleeding risk. The primary outcome of this retrospective cohort study was to assess the development o...