Venlafaxine (VEN), a drug used in the treatment of depression, undergoes significant first-pass metabolism after oral dosing to O-desmethylvenlafaxine (ODV), a metabolite with comparable therapeutic activity to that of parent drug. The pharmacokinetic disposition of VEN was characterized using a "first-pass" model that incorporates a presystemic compartment (liver) to account for the first-pass...

Introduction Non-invasive Fluorescent Reflectance Imaging (FRI) is used for accessing physiological and molecular processes in biological media. The aim of this article is to separate the overlapping emission spectra of quantum dots within tissue-equivalent phantom using SVD, Jacobi SVD, and NMF methods in the FRI mode. Materials and Methods In this article, a tissue-like phantom and an optical...

In this paper, a band-pass filter (BPF) based on split-ring resonator (SRR) using 3-D printing technique for C-band applications is introduced. The proposed designed to operate at frequency of 3.9 GHz. An innovative the substrate with size 24 x 1.1 mm3 PLA dielectric material implemented. copper sheet thickness 0.1 mm printed upper and lower faces substrate. First, SRR band stop (BSF) introduce...