Abstract Objective/background Lemborexant is a dual orexin receptor antagonist approved in the United States, Japan, and Canada for treatment of insomnia adults. We report effectiveness safety outcomes subjects with who received up to twelve months continuous lemborexant Study E2006-G000-303 (Study 303; SUNRISE-2). Patients/methods 303 was twelve-month, global, multicenter, randomized, double-b...

We determined the prevalence of tick-borne pathogens in domestic dogs using microscopy and polymerase chain reaction (PCR) techniques. A total of 303 EDTA blood samples were collected from domestic dogs in Khon Kaen Province, Thailand, in May 2013. Microscopic observation of Giemsa-stained smears and molecular diagnosis using conventional PCR were performed. Infected dogs were treated with imid...

The binary system, LS I ]61¡303, is unusual both because of the dramatic, periodic, radio outbursts, and because of its possible association with the 100 MeV gamma-ray source, 2CG 135]01. We have performed simultaneous radio and Rossi X-Ray T iming Explorer X-ray observations at 11 intervals over the 26.5 day orbit, and in addition searched for variability on timescales ranging from millisecond...

To investigate the mechanisms by which O-linked -Nacetylglucosamine modification of nucleocytoplasmic proteins (O-GlcNAc) confers stress tolerance to multiple forms of cellular injury, we explored the role(s) of O-GlcNAc in the regulation of heat shock protein (HSP) expression. Using a cell line in which deletion of the O-GlcNAc transferase (OGT; the enzyme that adds O-GlcNAc) can be induced by...

TaGS5 genes were cloned from bread wheat and were physically mapped on 3AS and 3DS. Sequencing results revealed that a SNP was found in the sixth exon of TaGS5-A1 gene. The SNP resulted in amino acid change from alanine to serine at the 303 bp position of TaGS5-A1. These two alleles were designated as TaGS5-A1a (alanine at the 303 bp position) and TaGS5-A1b genes (serine at the 303-bp position)...

Pathogen inactivation systems are in use in many European countries as routine procedures. However, a pathogen inactivation system for erythrocytes is currently not available. Although significant improvements have been made to decrease the incidence of transfusion-transmitted infections, risks remain for infectious disease agents specific to red blood cell concentrates, such as parasitic infec...

BACKGROUND In many regions of the world, wild mammals act as reservoir of Mycobacterium bovis, a situation that prevents the eradication of bovine tuberculosis. In order to observe whether a strain isolated from a wild boar, previously tested as highly virulent in a mice model, is also virulent in cattle, we performed cattle experimental inoculation with this strain RESULTS Groups of Friesian...

Several works have demonstrated the existence of a link between Mycobacterium avium subsp. paratuberculosis (MAP) and MS in Italy. In this study, we analyzed the serology of MAP in a Japanese population while looking at several markers of MAP. Fifty MS patients, 12 clinically isolated syndrome (CIS) patients, 30 other neurological disorders (OND) patients, and 50 healthy controls (HCs) were tes...

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Objectives To identify how frequently patient-reported outcomes (PROs) are used as primary and/or secondary in randomised controlled trials (RCTs) and to summarise what statistical methods for the analysis of PROs. Design Comprehensive review. Setting RCTs funded published by United Kingdom’s (UK) National Institute Health Research (NIHR) Technology Assessment (HTA) Programme. Data sources elig...