The endoglin heterozygous (Eng(+/-)) mouse, which serves as a model of hereditary hemorrhagic telangiectasia (HHT), was shown to express reduced levels of endothelial NO synthase (eNOS) with impaired activity. Because of intricate changes in vasomotor function in the Eng(+/-) mice and the potential interactions between the NO- and prostaglandin-producing pathways, we assessed the expression and...

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The objective was to develop, from a pool of clinical electronystagmography (ENG) data, normal lower limits for the corneo-retinal potential (CRP). The CRP evaluated in the present study was derived as a byproduct of eye movement calibration with a computerized ENG system. The data set was collected from a cohort of patients without history of ophthalmic disease. This normative study was design...

The ‘eng-genes’ concept, in which system-related nonlinearities are used as hidden-layer activation functions, has proven effective in the context of nonlinear systems modelling. This concept is now extended to control applications. An eng-genes network is integrated into a nonlinear adaptive controller and applied to a simulation of the Continuous Stirred Tank Reactor (CSTR), an application wi...

A novel neural modelling method, namely ‘eng-genes’, is proposed for complex nonlinear dynamic engineering systems. This method performs system modelling by first establishing the ‘eng-genes’ – some fundamental engineering functions from 'a priori' engineering knowledge, which are then constructed and coded into appropriate chromosome representations. Given a suitable fitness function, using ev...

Background Immunotherapy with T cells or bispecific T cell engagers is one promising approach to improve outcomes for patients with CD19-positive hematological malignancies. We had previously shown that T cells expressing bispecific T cell engagers that recognize CD19 and CD3 (CD19-ENG T cells) are activated in an antigen dependent manner, recruit resident T cells to tumors, and have anti-tumor...