National experience shows that 50 percent of physicians change positions within the first 2 years of practice. Because of market pressures, medicine in general and plastic surgery in particular are shifting away from solo practice. The authors examine the primary reasons for turnover and discuss job search priorities for recent plastic surgery graduates and established surgeons in job transitio...

The search for beauty and its value has been a discussion topic since the ancient Greeks composed their myths. The advent of safer and more advanced modern plastic surgery techniques and the spread of aesthetic medicine have renewed the search for beauty. Today, beauty seems possible, accessible, and more demo­ cratic than ever before [1]. To be beautiful is going to become an imperative, and f...

background: wearing spectacles is the most common approach in correcting the refractive errors worldwide. due to harmful effects of overexposure to solar ultraviolet radiations, the usage of multi-layer coatings in ophthalmic lenses has recently been increased. these lenses can reduce the reflections and hence increase the transmission of visible light; they can also decrease the transmission o...

Spinal muscular atrophy (SMA), characterized by specific degeneration of spinal motor neurons, is caused by mutations in the survival of motor neuron 1, telomeric (SMN1) gene and subsequent decreased levels of functional SMN. How the deficiency of SMN, a ubiquitously expressed protein, leads to spinal motor neuron-specific degeneration in individuals affected by SMA remains unknown. In this stu...

The pharmacokinetics, metabolism, and excretion of cobimetinib, a MEK inhibitor, were characterized in healthy male subjects (n = 6) following a single 20 mg (200 mCi) oral dose. Unchanged cobimetinib and M16 (glycine conjugate of hydrolyzed cobimetinib) were the major circulating species, accounting for 20.5% and 18.3% of the drug-related material in plasma up to 48 hours postdose, respectivel...

Abreu-Martin, Maria T., Andrew A. Palladino, Mary Faris, Nelson M. Carramanzana, André E. Nel, and Stephan R. Targan. Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G599–G605, 1999.—Fas is expressed constitutively by colonic epithelial cells, and its ligand is expressed by intraepithelia...

Jones, Michael K., Rabiha M. Itani, Hongtao Wang, Morimasa Tomikawa, I. James Sarfeh, Sandor Szabo, and Andrzej S. Tarnawski. Activation of VEGF and Ras genes in gastric mucosa during angiogenic response to ethanol injury. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1345–G1355, 1999.—Our previous studies demonstrated that ethanol injury triggers the angiogenic response in gastric mu...

I Introduction In recent years, specialists in human–computer interaction (HCI) have come to appreciate the importance of understanding the context in which computer-supported activities take place [1]. Such understanding directly affects design and evaluation by revealing what users are up to and how they might most effectively use a technology. The idea is to gain this understanding before th...