Bone tissue is densely innervated, and there is increasing evidence for a neural control of bone metabolism. Semaphorin-3A is a very important regulator of neuronal targeting in the peripheral nervous system as well as in angiogenesis, and knockout of the Semaphorin-3A gene induces abnormal bone and cartilage development. We analyzed the spatial and temporal expression patterns of Semaphorin-3A...

Background and aims The aim for this study was to assess the construct validity and reliability of the Health Dialogue Questionnaire (HDQ©) for eleventh grade in school through comparison of the HDQ© with Paediatric Quality Of Life Inventory (PedsQL™), Local monitoring of youth policy questionnaire (LUPP®), Health behaviour in Swedish school-aged children (HBSC©), Equal health (EH©) and The Swe...

We experimentally explore the effects and interactions of three variables considered important when bargaining over a jointly produced surplus: performance information, production uncertainties when translating performance into output, and subjective entitlements derived from the production process. We find that without performance information subjective entitlements are mostly mutually consist...

Purpose: We propose in this paper to analyze what are the factors that influence knowledge transfer both intra and intergenerational in family firms. The main objective is to establish a framework that can be used later in empirical research, although we maintain a completely theoretical approach in this paper Design/methodology/approach: This study, which is a comprehensive framework character...

A functional approach for the study of the random walks in random sceneries (RWRS) is proposed. Under fairly general assumptions on the random walk and on the random scenery, functional limit theorems are proved. The method allows to study separately the convergence of the walk and of the scenery: on the one hand, a general criterion for the convergence of the local time of the walk is provided...

We used learning-to-rank methods for training ranking model. Due to the limited number of training queries, we split them and conducted 5-fold cross validation. We set the proportion of training and testing as 4 : 6. For the features used in learning the model, a total of 231 features that are from multiple information retrieval models with different parameter settings were adopted. For the bas...

BACKGROUND Induction of cellular senescence through activation of the p53 tumor suppressor protein is a new option for treating proliferative disorders. Nutlins prevent the ubiquitin ligase MDM2 (murine double minute 2), a negative p53 regulator, from interacting with p53. We hypothesized that cell senescence induced by Nutlin-3a exerted therapeutic effects in pulmonary hypertension (PH) by lim...