نتایج جستجو برای: 3a5 cpy
تعداد نتایج: 371 فیلتر نتایج به سال:
Cytochrome P450 (P450)-dependent metabolism of all-trans-retinoic acid (atRA) is important for the expression of its biological activity. Because the human P450s involved in the formation of the principal atRA metabolites have been only partially identified, the purpose of this study was to identify the human P450s involved in atRA metabolism. The use of phenotyped human liver microsomes (n = 1...
[Ru(bpy)2(PVP)10] (RuPVP (bpy = 2,2-bipyridyl; PVP = poly(4-vinylpyridine)) was synthesized and characterized as described previously. Styrene (MW= 104.15), 2Acetylaminofluorene (2-AAF, MW= 223.27), 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, MW= 207.23), poly(diallyldimethylammonium chloride) (PDDA, average Mw= 100,000200,000), poly(sodium 4-styrenesulfonate) (PSS, average MW= 70000),...
Dronedarone is an antiarrhythmic agent approved in 2009 for the treatment of atrial fibrillation. An in-house preliminary study demonstrated that dronedarone inhibits cytochrome P450 (CYP) 3A4 and 3A5 in a time-dependent manner. This study aimed to investigate the inactivation of CYP450 by dronedarone. We demonstrated for the first time that both dronedarone and its main metabolite N-desbutyl d...
Dronedarone is an antiarrhythmic agent approved in 2009 for the treatment of atrial fibrillation. An in-house preliminary study demonstrated that dronedarone inhibits cytochrome P450 (CYP) 3A4 and 3A5 in a time-dependent manner. This study aimed to investigate the inactivation of CYP450 by dronedarone. We demonstrated for the first time that both dronedarone and its main metabolite N-desbutyl d...
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