The mechanism of uptake of Adriamycin was investigated in chick embryo heart and liver cells and in murine L5178Y lymphoblasts in vitro. Drug uptake at 4°C for 15 s due to rapid association accounted for a celhmedium distribution ratio of 104 ±14 (SE) in heart cells, 10.2 ±1.3 in liver cells, and 10.3 ±1.5 in L5178Y lymphoblasts. On thin-layer Chromatographie analysis, 98% of the radioactiv...

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To characterize the excretion of 2-mercaptoethanesulfonate sodium (mesna) administered by intermittent infusion, urinary concentrations of mesna and its corresponding inactive disulfide »eremeasured during 50 courses of ifosfamide (1.6 g/nr for 5 days) and mesna (400 mg/nr at 0.25, 4, and 6 h after each ifosfamide dose) administered i.v. to 19 patients. Some patients had previously received ne...

The electrical potential difference (P.D.) across the cell membrane was measured in monolayers of HeLa cells. At 37°C in the cells' growth medium, the mean P.D. was found to be —1 5.45 ±0.57 my, the cell interior being negative. In Tris buffer the P.D. was —17.10 ±0.71 my. The PD. was tempera ture sensitive, falling to —11.9 my at 27°Cand —9.12my at 17°C.Increasing extracellular K ...

â  â  â  â â â  methods of speakers' effects on the audience â  â nasrollah shameli * â  fariba hosayni ** â â â  abstract â  this article is focused on four issues. the first issue is related to the speaker's external appearance including the beauty of face, the power of his voice, moves and signals by hand, the stick and eyebrow as well as the height. such characteristics could have...

The effects of 3-O-methyl-D-glucose (3-OMG) on subcutaneously implanted murine radiation-induced fibrosarcoma 1 tumor were examined with 'H, "(.', and "I" nuclear magnetic resonance (NMR) in situ. Using 31P NMR, changes in tumor high-energy phosphate metabolism were monitored for 2.5 h after i.p. administration of 3-OMG (8.1 g/kg body weight); tumor pH decreased by a mean maximum of 0.52 ±0.05...