BACKGROUND AND AIMS  Endoscopic resection techniques require use of submucosal injection. The aim of this study was to assess a new solution that combines hyaluronic acid, chondroitin sulfate, and poloxamer 407 for submucosal injection. METHODS  A total of 48 gastric submucosal cushions were created in fresh porcine stomachs using gelafundin (n = 16) or the new solution diluted at 50 % (n = 1...

Intratumoral infusion is the most commonly used method for viral gene delivery in clinical trials for cancer treatment. However, a potential problem in this approach is that viral vectors may disseminate from tumor to normal tissues during and after the infusion. To reduce the dissemination, we developed a novel method based on a biocompatible polymer, poloxamer 407, which could significantly i...

Thermosensitive systems based on poloxamer 407 are widely used in targeted drug delivery; however, the stability of phase transition temperature remains insufficiently studied. This article presents results a study effect adding polyethylene glycols (PEG) with different molecular weights and some classical gel-forming polymers gelation thermoreversible compositions long-term experiment. The sho...

Obesity and dyslipidemia are conditions often associated with cardiovascular risk, inflammation, oxidative stress, death. Thus, a new approach has been highlighted to promote research development of pharmacological tools derived from natural sources. Among the most widely studied groups substances, polyphenols such as tyramine stand out. This study investigated hypolipidemic anti-obesity proper...

This paper presents the biomechanical finite element models that have been developed in the framework of the computer-assisted maxillofacial surgery. After a brief overview of the continuous elastic modelling method, two models are introduced and their use for computer-assisted applications discussed. The first model deals with orthognathic surgery and aims at predicting the facial consequences...