BACKGROUND XaraColl(®), a collagen-based implant that delivers bupivacaine to the site of surgical trauma, is under development for postoperative analgesia. Because of differing patient attitudes to postoperative pain control and the inability to assess baseline pain, standard clinical methods for evaluating analgesic efficacy are compromised and justify application of novel integrated approach...

Healthy term babies undergo a physiological nadir in serum calcium levels by 24-48 hours of age. The nadir may be related to the delayed response of parathyroid and calcitonin hormones in a newborn. This nadir may drop to hypocalcemic levels in high-risk neonates including infants of diabetic mothers, preterm infants and infants with perinatal asphyxia. The early onset hypocalcemia which presen...

OBJECTIVES Early identification of potential recovery of postanoxic coma is a major challenge. We studied the additional predictive value of EEG. METHODS Two hundred seventy-seven consecutive comatose patients after cardiac arrest were included in a prospective cohort study on 2 intensive care units. Continuous EEG was measured during the first 3 days. EEGs were classified as unfavorable (iso...

Seedlings of corn (Zea mays) were tested for recovery from chilling injury incurred at 0.3 +/- 0.3 C. At 0.3 C visual leaf injury appeared in 36 hours, whereas stem and root injuries appeared later. Appearance of leaf injury was preceded by a rise in O(2) uptake and a lessened effect of 2,4-dinitrophenol on O(2) uptake by leaf segments and was accompanied by increased ion leakage from the leave...

BACKGROUND The aim of this study was to evaluate the safety and practicality of very early (within 48 h) discharge with long-term follow-up results, and to define an optimal length of stay in hospital for patients with ST elevation myocardial infarction (STEMI) according to their demographic characteristics and risk assessment. METHODS A total of 267 patients with STEMI successfully treated w...

BACKGROUND AND PURPOSE Liver regeneration develops after partial hepatectomy. This study investigated the enhancement of oxidative phosphorylation in liver regeneration and its correlation to mitochondrial calcium ion in rats. METHODS Respiratory functions of mitochondria isolated from regenerating rat liver 24, 48, 72, and 96 hours after 70% hepatectomy were studied including state 3 and sta...

This meta-analysis and systematic review aimed to attain specific data on the effect of branched-chain amino acids (BCAAs) administration on muscle injuries and the indices of delayed-onset muscle soreness (DOMS) after exercise. Literature search was performed in databases such as Scopus, ISI, Web of Science, Scientific Information Database (SID), Cochrane Controlled Register of Trials (CENTRAL...

Background: β-Blockers have shown considerable cytotoxic, anti-tumor and anti-angiogenic effects. Metoprolol, a β-Blocker with anti-inflammation, anti-tumor and anti-angiogenic properties has been widely used for treatment of some cardiovascular diseases such as angina, hypertension, heart failure and myocardial infraction. Limited data exist about the cytotoxic effects of metoprolol on human c...