نتایج جستجو برای: 5 مترونیدازول
تعداد نتایج: 1215946 فیلتر نتایج به سال:
Aminoglycoside antibiotics: Synthesis of 5"-amino-5"-deoxyneomycin and 5"-amino-5"-deoxyparomomycin.
DNA methylation (5-methylcytosine, 5mC) plays critical biological functions in mammals and plants as a vital epigenetic marker. The Ten-Eleven translocation dioxygenases (TET1, 2, and 3) have been found to oxidize 5mC to 5-hydroxymethylcytosine (5hmC) and then to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in mammalian cells. We report herein three mushroom TET homologues from Coprinop...
Emerging data strongly suggest that the oxidation of DNA bases can contribute to genomic instability. Structural changes to DNA, induced by base oxidation, may reduce the fidelity of DNA replication and interfere with sequence-specific DNA-protein interactions. We have examined the structures of a series of pyrimidine deoxynucleoside oxidation damage products in aqueous solution. The modified n...
سابقه و هدف: هلیکوباکترپیلوری یکی از شایع ترین عفونتهای مزمن در دنیا است. اعتقاد بر این است که دیابت قندی باعث افزایش ابتلا به عفونت هلیکوباکترپیلوری می شود، اما داده های مرتبط در مورد ارتباط هلیکوباکترپیلوری و میزان کنترل قند خون (hba1c) در دیابتی ها اندک و متناقض می باشد. براین اساس مطالعه حاضر با هدف بررسی اثر ریشه کنی عفونت هلیکوباکترپیلوری در کنترل قند خون بیماران دیابتی انجام گرفت. مواد ...
Individual DNA molecules can be read at single nucleotide precision using nanopores coupled to processive enzymes. Discrimination among the four canonical bases has been achieved, as has discrimination among cytosine, 5-methylcytosine (mC), and 5-hydroxymethylcytosine (hmC). Two additional modified cytosine bases, 5-carboxylcytosine (caC) and 5-formylcytosine (fC), are produced during enzymatic...
5-Methylcytosine (5 mC) is associated with epigenetic gene silencing in mammals and plants. 5 mC is consecutively oxidized to 5-hydroxymethylcytosine (5 hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by ten-eleven translocation enzymes. We performed binding and structural studies to investigate the molecular basis of the recognition of the 5 mC oxidation derivatives in the context o...
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