Hypothyroidism significantly reduced the mean amplitude and increased the mean frequency of spontaneous rhythmic contractions in 18 day pregnant rat uterus. Nifedipine (10(-12)-10(-9) M) and diltiazem (10(-10)-10(-6) M) caused concentration related inhibition of the myogenic responses of the uterine strips obtained from both pregnant and hypothyroid state. However, nifedipine was less potent (I...

Solanum asterophorum Mart. (Solanaceae) is a shrub popularly known as "jurubeba-defogo" in the northeast of Brazil. In the present work, the methanol extract (SA-MeOH, 3750 microg/mL) and isojuripidine (10(-7) - 3 x 10(-4) M), a steroidal alkaloid obtained from S. asterophorum Mart. leaves, inhibited phasic contractions induced by both 1 microM histamine [IC50 = (225.8 +/- 47.4), g/mL and (3.5 ...

Wormholes have been advanced as both a method for circumventing the limitations of the speed of light as well as a means for building a time machine (to travel to the past). Thus it is argued that General Relativity may allow both of these possibilities. In this note I argue that traversable wormholes connecting otherwise causally disconnected regions, violate two of the most fundamental princi...

We report high-resolution, high-signal-to-noise, observations of the extremely metal-poor double-lined spectroscopic binary CS 22876–032. The system has a long period : P = 424.7 ± 0.6 days. It comprises two main sequence stars having effective temperatures 6300 K and 5600 K, with a ratio of secondary to primary mass of 0.89 ± 0.04. The metallicity of the system is [Fe/H] = –3.71 ± 0.11 ± 0.12 ...

BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous disorder with aberrant regulation of a variety of signal pathways. Therefore, simultaneous targeting of two or even more deregulated signal transduction pathways is needed to overcome drug resistance. Previously, it was reported that SNS-032, a selective cyclin-dependent kinase inhibitor, is an effective agent for treatment of AML; howe...

introduction: to write a computational program to calculate the average glandular dose in mammography with rh-rh target-filter and also use it as an accurate and fast method of dose calculation founder different situations. materials and methods: in this research, the sobol-wu parameters are used to write a fortran code for glandular dose calculation in rh-rh target-filter mammograms. the code ...

rhododendron dauricum l. is an ancient chinese traditional herb. the pharmacological effects of r. dauricum extract have been shown in chronic tracheitis. the aim of this study was to investigate the cardiovascular effects of rhododendron dauricum l. flavonoids (rf) on rats and its mechanisms. this study was performed in isolated vascular rings and a rat model of myocardial infarction and isola...

of abutments with two different diameters and transmucosal heights used for cementretained implant-supported prostheses in Morse-taper implants. Forty Morse-taper implants were divided into four groups with different abutment sizes for cement-retained prostheses in order to perform the compressive test. The groups were divided by abutment diameter and transmucosal height as follows: Group 1: 4....

A novel hopanoid, 30-(5'-adenosyl)hopane, was isolated from the purple non-sulphur bacterium Rhodopseudomonas acidophila and identified. The significance of this triterpenoid in terms of bacteriohopanepolyol biosynthesis, membrane reinforcement and possible interactions with nucleic acids is discussed.