the clinical potentials of stem cells in cell-based therapies have raised great hopes in diabetes mellitus as well. however, there are complex ethical, legal, and socio-cultural issues surrounding the subject. in this paper, we intend to review in brief the main ethical issues for endocrinologists and other clinicians who are interested and work in the field of cell therapy and research.

background: there is evidence that mesangial cell structural changes contribute to the pathogenesis of diabetic nephropathy. to gain better insight into the mechanisms responsible for this issue, present study focused on effect of cord blood mononuclear cells (mncs) derived cd133 positive cells on mesangial cell structure and function. materials and methods: the animals were randomly divided in...

Objective(s): The significant contribution of nanoparticles to cancer treatment has attracted therapeutic attention. The present study aimed to evaluate the synergistic effects of 5-fluorouracil (5-FU) and zinc oxide nanoparticles (ZnO NPs) as multimodal drug delivery on human breast cancer MCF-7 cells.Materials and Methods: In this in-vitro study, the impact of 5-FU and ZnO NPs in the sin...

Global DNA de-methylation is thought to occur only during pre-implantation and gametogenesis in mammals. Scalable, cell-wide de-methylation has not been demonstrated beyond totipotent stages. Here, we observed a large scale de-methylation and subsequent re-methylation (CDR) (including 5-methylcytosine (5mC) and 5-hydroxylmethylcytosine (5hmC)) in post-mitotic cerebellar Purkinje cells (PC) thro...

Analysis of six different cell types of normal and transformed fibroblasts grown in vitro and of four different cell types of normal and leukemic lymphocytes grown in vivo have shown a marked decrease of 3- to 30-fold in the specific activity of 5'-nucleotidase in the malignant cells as compared to their normal parental cells. The results have also indicated that a serum stimulation of untransf...