IgG antibodies are the basis of some of the most effective therapeutics developed over the last 20 years. These antibodies are highly specific, have long serum-half lives, and can be produced relatively routinely, making them ideal drugs for immunotherapy. The degree of regulation on IgG antibody effector functions by the composition of the single, N-linked glycan attached to the Fc is increasi...

Background: Brucellosis is the major bacterial zoonoses of global importance caused by Brucella spps. FCγRIIA receptor plays a central role in phagocytosis of IgG2-opsonized bacteria. FCγRIIA exhibits allelic polymorphisms with different capacities for binding IgG2 and phagocytosis. Cells expressing Fc γ RIIa-H131, bind more efficiently to complexes of IgG2 than those expressi...

anise hyssop is a prennial herb belonging to the lamiaceae family. essential oil of this plant is used in food, pharmaceuticals, cosmetics industries as well as flavoring liqueurs. since water stress affects the growth, productivity, as well influences the active principles governing medicinal plants, in this research the effect of different water deficit stresses on such morphological traits a...

BACKGROUND The fundamental determinant of the natural history of Chagas' disease is cardiac involvement. METHODS AND RESULTS We studied 104 male patients with congestive heart failure due to Chagas' disease to estimate the survival distribution function and to evaluate age, functional class (FC), maximal oxygen consumption (VO2max), and ejection fraction (EF) as predictors of survival. Statis...

Background & Aim: Osmotic stress in plants lead to increase free radicals and plants use different mechanisms to scavenge these radicals. So, researchers apply stresses especially drought stress to increase secondary metabolites such as phenolics, and antioxidants. One of the valuable medicinal plants is yarrow (Achillea tenuifolia) which is a perennial plant with different medicinal a...

Background: Febrile convulsion (FC) and urinary tract infection (UTI) account for a large number of visits to pediatric emergency departments and both are common during early childhood. The aim of this study was to determine the prevalence of UTI among children presenting with FC. Methods: In this prospective study, children with FC who presented to a pediatric emergency department were consecu...

Dietary habits such as caloric restriction or nutrients that mimic these effects may exert beneficial effects on brain aging. The plant-derived polyphenol resveratrol has been shown to increase memory performance in primates; however, interventional studies in older humans are lacking. Here, we tested whether supplementation of resveratrol would enhance memory performance in older adults and ad...

We studied the physical behavior of PdO nanoparticles at low temperatures, which presents an unusual clearly related to macroscopic quantum tunneling. The samples show a tetragonal single phase with P42/mmc space group. Most importantly, particle size was estimated about 5.07 ± 1.97 nm. Appropriate techniques were used determine characteristic these nanoparticles. most important aspect this stu...

The manageable toxicity profile of obinutuzumab (GA101; G) alone or with chemotherapy in first-line (1L; fit and non-fit) relapsed/refractory (R/R) patients chronic lymphocytic leukaemia (CLL) was established the primary analysis Phase IIIb GREEN trial (Clinicaltrials.gov: NCT01905943). final (cut-off, 31 January 2019) is reported here. Patients received G (1000 mg) (G-mono; non-fit patients) [...