The title compound, C(19)H(19)N(7)O(5), exhibits substitutional disorder of the ortho-nitro and cyano groups, with site-occupancy factors of 0.686 (7):0.314 (7). The two aromatic rings are essentially coplanar, with a dihedral angle of 6.6 (5)°. In the diethyl-amino group, the two ethyl groups lie on the same side of the amino-benzene plane. An intra-molecular N-H⋯N hydrogen bond links the amin...

The green synthesis of 5-(4-aminophenyl)-4-aryl-4H-1,2,4-triazole-3-thiol was achieved in four steps, In first step, 4-amino benzoic acid refluxed in ethanol along with catalyst Conc. Sulphuric acid to produce ethyl-4-amino benzoate I. Further compound I refluxed with hydrazine hydrate in ethanol to produce 4-amino benzohydrazide II. Compound II refluxed in ethanolic potassium hydroxide with ca...

An environmentally friendly, green, and highly efficient process for the synthesis of biologically and pharmacologically  4H-benzo[b]pyrans  and  3,4-dihydropyrano [c] chromenes  is  developed  by condensing cyclic aromatic aldehydes, malononitrile, and dimedone or 4‐hydroxycoumarin in the presence  of  lactic  acid  as  an  efficient  and  green  catalyst.  The corresponding  products  have  b...

The reactions of isatins, 3-amino-1-pheyl-1H-pyrazol-5(4H)-one, and monocyclic ketones, have been developed for preparation spiro[indoline-3,4'-pyrazolo[3,4-b]quinoline]-2,3'(6'H)-dione, spiro[cyclohepta[b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2′,3-dione, spiro[cycloocta[b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2′,3(6H)-dione, spiro[cyclo dodeca[b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2′,3(6H...

Silica-bonded n-propyltriethylene-tetramine (SBNPTT) was found as an efficient solid base for the synthesis of 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes. Chromene derivatives were obtained via the three-component condensation reaction of aromatic aldehydes, malononitrile, and dimedone at 80 oC under solvent-free conditions. The heterogeneous solid base showed much the same efficiency when u...

In order to explore potent derivatives of pradimicins (PRMs), modification of their C4'-amino group was carried out. 4'-N-Cyano (1,2), 4'-deamino-4'-nitroguanidino (4), 4'-deamino-4'-ureido (7-9) and 4'-deamino-4'-thioureido (10) derivatives were synthesized by trimethylsilylation of PRMs A and C, followed by condensation with appropriate reagents. 4'-Deamino-4'-guanidino (5) and 4'-deamino-4'-...