Antigen may be demonstrated by radioautography or immunofluorescence to bind to the surface of individual small lymphocytes. Antigen-binding cells (ABC),I specific for any given antigen, are rare in nonimmunized animals and increase in frequency after immunization. These cells possess easily detectable amounts of surface immunoglobulin and the blocking of this immunoglobulin inhibits antigen bi...

The choice of a formula for the antigen is limited by four considerations: (1) The anticomplementary action of the antigen. (2) The complement-fixing properties of the antigen. (3) The occurrence of floccules when the antigen is made in saline suspensions. (4) The unit strength of the formula to be employed. It has already been shown (Price, 1953a, b) that as far as the anticomplementary proper...

Coxsackievirus B3 (CVB3) infection induces myocardial inflammation and myocyte necrosis in some, but not all, strains of mice. C57BL/6 mice, which inherently lack major histocompatibility complex (MHC) class II IE antigen, develop minimal cardiac lesions despite high levels of virus in the heart. The present experiments evaluate the relative roles of class II IA and IE expression on myocarditis...

BACKGROUND The most effective measure in house dust mite antigen reduction is mattress encasing with an impermeable membrane. A reduction in encasing costs will help increase patients' compliance in mite antigen avoidance. OBJECTIVE To investigate the effectiveness of partial mattress encasing with a nylon sheet produced in Thailand on the reduction of group I mite antigens from beddings. M...

Background: The strong association of Behcet’s disease with HLA-B5 antigen has been observed in several ethnic groups from Middle East to Far East. Objective: To evaluate the frequency and association of HLA-B5 and also likelihood ratio of involvement in Behcet’s disease in a group of Iranian patients. Patients and Methods: HLA-B5 antigen typing was performed by serologic method in 56 patients ...

to study the immunohistochemical pattern of cd 117, glial fibrillary acidic protein (gfap), smooth muscle actin (sma) and cd 43 in pleomorphic adenoma (pa), adenoid cystic carcinoma (adcc) and polymorphous low grade adenocarcinoma (plga) of minor salivary glands.twenty cases of pa, 20 cases of adcc and 10 cases of plga were retrieved from record files along with their paraffin blocks at armed f...

The bcl-6 proto-oncogene encodes a POZ/zinc finger transcriptional repressor expressed in germinal center (GC) B and T cells and required for GC formation and antibody affinity maturation. Deregulation of bcl-6 expression by chromosomal rearrangements and point mutations of the bcl-6 promoter region are implicated in the pathogenesis of B-cell lymphoma. The signals regulating bcl-6 expression a...

Staining with CD14 and CD16 monoclonal antibodies will identify two monocyte subpopulations in human blood: a major population of regular monocytes, which strongly expresses the CD14 antigen (CD14++), and a minor population with weak expression of CD14 and expression of the CD16 antigen (CD14+/CD16+ cells). As shown herein, the latter cells account for 45 +/- 22 cells/microL and 9% +/- 5% of th...

Xenotransplantation reemerged as a promising alternative to conventional transplantation enlarging the available organ pool. However, success of xenotransplantation depends on design and selection specific genetic modifications development robust assays allowing for precise assessment tissue-specific immune responses. Nevertheless, cell-based are often compromised by low proliferative capacity ...

• We conducted transcutaneous vaccination using a dissolving microneedle patch. verified the immune induction mechanism of vaccination. Production some cytokines and chemokines was rapidly induced in skin. Migration skin-resident antigen-presenting cells to lymph nodes promoted. T B cell differentiation more enhanced than subcutaneous immunization. Transcutaneous immunization (TCI) is an appeal...