BACKGROUND Arsenic is known as an endocrine disruptor that people are exposed to through various sources such as drinking water and indigestion of marine products. Although some epidemiological and animal studies have reported a correlation between arsenic exposure and diabetes development, there are limited studies regarding the toxic effects of organic arsenic including arsenobetaine on the h...

TOPIC: Sleep Disorders TYPE: Original Investigations PURPOSE: disordered breathing (SDB) is common in pregnancy. A relationship has been described late pregnancy between SDB and abnormal glucose metabolism, gestational diabetes mellitus (GDM). However, it remains unclear whether this starts early or develops following exposure to pregnancy.The goal of the current study examine association its s...

Homa is a new transport protocol for datacenter networks. It provides exceptionally low latency, especially for workloads with a high volume of very short messages, and it also supports large messages and high network utilization. Homa uses in-network priority queues to ensure low latency for short messages; priority allocation is managed dynamically by each receiver and integrated with a recei...

OBJECTIVES The aim of this study was to investigate the clinical and biochemical profiles according to homeostasis model assessment of insulin resistance (HOMA-IR) in Korean polycystic ovary syndrome (PCOS) patients. METHODS In 458 PCOS patients diagnosed by the Rotterdam European Society for Human Reproduction and Embryology (ESHRE) criteria, measurements of somatometry, blood test of hormon...

OBJECTIVE To assess the acute effects of blood transfusion on insulin sensitivity and pancreatic β-cell function in thalassemia patients. METHODS Fifty children and adolescents with β-thalassemia/HbE disease were enrolled in a prospective cohort study. Hemoglobin, serum ferritin and oral glucose tolerance test (OGTT) were performed prior to, and one week after blood transfusion. Insulin sensi...

AIMS To study the relationship between thioredoxin-interacting protein (TXNIP) and pancreatic β-cell function in patients with impaired glucose regulation and patients with both impaired glucose regulation and hypertriglyceridemia. METHODS We analyzed a population of 90 patients with impaired glucose regulation (IGR), 87 patients with IGR and hypertriglyceridemia, and 90 subjects with normal ...

BACKGROUND AND PURPOSE The independent contribution of insulin resistance to atherosclerosis is still under debate. We compared associations of 2 different indices of insulin resistance, the Homeostasis Model Assessment (HOMA) index and kITT from a short insulin tolerance test with carotid atherosclerosis. METHODS A total of 1771 middle-aged white patients were investigated. Intima media thic...

Increased insulin resistance is a therapeutic target in patients with chronic liver disease. Branched-chain amino acids (BCAA) have been reported to improve insulin resistance in in vivo experiments. Thus, we investigated the effects of BCAA on insulin resistance in patients with chronic liver disease. Twelve patients with chronic liver disease were enrolled. Each patient was given one sachet o...

OBJECTIVE We sought to determine whether insulin resistance predicts the incidence and progression of coronary artery calcification (CAC). RESEARCH DESIGN AND METHODS We studied 5,464 participants not on hypoglycemic therapy from the Multi-Ethnic Study of Atherosclerosis (MESA). Each had baseline homeostasis model assessment of insulin resistance (HOMA-IR) and baseline and follow-up CAC score...

OBJECTIVES To determine the relationship between body mass index (BMI), homeostasis model assessment insulin resistance (HOMA-IR) and insulinemia. METHODS This was a prospective cross-sectional observational study of 132 prepubescent schoolchildren residents in the municipality of Santo André, Brazil. Children underwent anthropometric assessment, their glycemia and insulinemia were measured a...