I have read the report of Olivieri et al’ in the May 1, 1994 issue of BLOOD. Although the investigators stated that “in standard practice, treatment options are limited to two: steroid therapy or RBC transfusions,” they ignore our very good results obtained with megadose methylprednisolone (MDMP; initial dose 30 to 100 mgkg/d for 3 days followed progressive halving of the dose every 4 to 7 days...

During both acute and chronic mineralocorticoid administration, parotid saliva was obtained by acetylcholine stimulation at rates of 1-0—1 -5 mlmin" from anaesthetized red kangaroos. The Na/K ratio of saliva from chronically Na-replete kangaroos was virtually unaltered by ipsilateral intracarotid infusion of aldosterone at rates of 8, 40 or 80/igh" for 4h, the ratio falling from 20-1 ± 1-09 to ...

BACKGROUND Vegetables constitute a vital part of the human diet, being the main source of minerals, vitamins, dietary fibre and phytochemicals. They however, also contain nitrates and nitrites, which adversely affect human health. OBJECTIVE To determine nitrate and nitrite content in selected vegetables purchased at supermarket chains in Siedlce and to assess their impact on consumer health. ...

In the present study, we examined whether the powerful antioxidant probucol (a clinically used lipid-lowering drug) would attenuate the oxidative stress and energy starvation in experimental model of heart failure (HF) using isoproterenol. Rats were injected subcutaneously with isoproterenol (2.4 mgkg-1) daily for 1 week, and then treated with probucol (61 mg/kg) daily for 2 weeks. Oxidative st...

The oxidative stability of margarine supplemented with different concentrations of fennel (Foeniculum vulgare) seed extract (FSE) was compared to the synthetic antioxidants; butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) at legal concentrations. The experiment was carried out under accelerated storage conditions for 4 weeks employing peroxide value (PV), p-anisidine value (AV...

Background & Aims of the Study:  Heavy metals are ubiquitous in the environment, as a result of both natural and anthropogenic activities, and humans are exposed to them through various pathways, especially food chain. So, this study aimed to assess heavy metals (Cu, Pb and Zn) concentrations in different parts of the leek vegetable in Hamedan Province, Iran. Materia...

To clarify the mechanisms by which Triton WR-1339 causes an elevation in the plasma fibrinogen level, we studied the time courses of hepatic mRNA expression for beta-chain fibrinogen, interleukin-6 (IL-6) and IL-6 receptor (R) by RT-PCR. After intravenous injection of Triton WR-1339 (150, 300 and 500 mg/kg) in Sprague-Dawley rats, the plasma level of fibrinogen and MCP-1 significantly and dose-...

Land use in east China tends to change from paddy rice to vegetables or other high-value cash crops, resulting in high input rates of organic manures and increased risk of contamination with both heavy metals (HMs) and antibiotics. This investigation was conducted to determine the accumulation, distribution and risks of HMs and tetracyclines (TCs) in surface soils and profiles receiving differe...