In the title compound, C(9)H(6)FNO(2), all the non-H atoms are approximately coplanar, the carb-oxy O atoms deviating by 0.0809 and -0.1279 Å from the indole plane. In the crystal, O-H⋯O hydrogen bonds link the mol-ecules into dimers which are linked via N-H⋯O hydrogen bonds and π-π inter-actions [centroid-centroid distance = 3.680 (2) Å].

In the title mol-ecule, C(9)H(6)BrNO(2), the dihedral angle between the -COOH group and the ring system is 6 (4)°. In the crystal, pairs of O-H⋯O hydrogen bonds link the mol-ecules into inversion dimers and these dimers are connected via N-H⋯O hydrogen bonds to form layers parallel to the (-101) plane.

The structure of the title compound, C(6)H(7)N(3)O(2), is of inter-est with respect to radiopharmacueticals. The crystal packing is characterized by N-H⋯O and O-H⋯N hydrogen bonds, which form a three-dimensional network. The molecule is planar except for one of the amine H atoms.

In the title compound, C13H8Cl3NO4S, the aromatic rings are oriented at a dihedral angle of 68.94 (1)° and the mol-ecule adopts a V-shape. An intra-molecular N-H⋯O inter-action generates a six-membered S(6) ring motif. In the crystal, pairs of O-H⋯O hydrogen bonds involving the carb-oxy group link the mol-ecules into inversion dimers with an R 2 (2)(8) motif. N-H⋯O and non-classical C-H⋯O inter...

6-Aminohexanoic acid is a potent antifibrinolytic agent with the ability to retard dissolution of fibrin clots. The corneal penetration of 6-aminohexanoic acid was measured to determine if therapeutic levels of the drug could be maintained in the anterior chamber by topical administration. The conjunctival sac to anterior chamber transfer coefficient was found to be 1.51 X 10-4 +/- 0.20 X 10-4 ...

Erythromycin A (1), a well-established macrolide antibiotic, is unstable under acidic conditions. When administered orally, 1 is in equilibrium with its 8,9-anhydro-6,9-hemiketal and is simultaneously converted directly to the antibacterially inactive 6,9:9,12-spiroketal1}. A number of research groups in recent years have prepared new derivatives of erythromycin A by modification of the functio...

OBJECTIVES To estimate the prevalence of overweight in children under five years old from urban households and to investigate associated factors. METHODS Cross-sectional population-based study carried out in the five regions of Brazil with a sample of 6,397 children. The World Health Organization 2006 Growth Curves were used and children were considered overweight when Z-score was higher than...

A local ring R is called Z-local if J(R) = Z(R) and J(R) = 0. In this paper the structures of a class of Z-local rings are determined.