Jutta Ernst, Heinz Böker, Joe Hättenschwiler, Daniel Schüpbach, Georg Northoff, Erich Seifritz, and Simone Grimm Clinic for Affective Disorders and General Psychiatry, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital, 8029 Zurich, Switzerland, Center for Anxiety and Depression, 8008 Zurich, Switzerland, University of Ottawa, Institute of Mental Health...

1,2BIN WU, MD, 2,3TUANQI SUN, MD, 1,2YAJIA GU, MD, 1,2WEIJUN PENG, MD, 2,3ZHUOYING WANG, MD, 2,4RUI BI, MD and 2,3QINGHAI JI Department of Radiology, Fudan University Shanghai Cancer Center (FUSCC), Shanghai, China Department of Oncology, Shanghai Medical College, Fudan Univerisity, Shanghai, China Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center (FUSCC), Shanghai, C...

The mouse subventricular zone (SVZ) generates large numbers of neuroblasts, which migrate in a distinct pathway, the rostral migratory stream (RMS), and replace specific interneurons in the olfactory bulb (OB). Here, we introduce an organotypic slice culture model that directly connects the RMS to the hippocampus as a new destination. RMS neuroblasts widely populate the hippocampus and undergo ...

D ow noad Fighting is dangerous, which is why animals choose to flee once the costs outweigh the benefits, but themechanisms underlying this decision-making process are unknown. By manipulating aggressive signaling and applying nitrergic drugs, we show that the evolutionarily conserved neuromodulator nitric oxide (NO), which has a suppressing effect on aggression in mammals, can play a decisive...

TheCXCL12/CXCR4 signaling pathway is involved in the development of numerous neuronal and non-neuronal structures. Recent work established that the atypical second CXCL12 receptor, CXCR7, is essential for the proper migration of interneuron precursors in the developing cerebral cortex. Two CXCR7-mediated functions were proposed in this process: direct modulation of β-arrestin-mediated signaling...

The gastrovascular system of colonial hydroids is central to homeostasis, yet its functional biology remains poorly understood. A probe (2′,7′-dichlorodihydrofluorescein diacetate) for reactive oxygen species (ROS) identified fluorescent objects at polyp-stolon junctions that emit high levels of ROS. A nuclear probe (Hoechst 33342) does not co-localize with these objects, while a mitochondrial ...

Diastereomeric adducts between (S)-1-(4-fluorophenyl)-ethanol and R and S 2-butanol, formed by supersonic expansion, have been investigated by means of a combination of mass selected resonant two-photon ionization-spectroscopy and infrared depletion spectroscopy. Chiral recognition is evidenced by the specific spectroscopic signatures of the S1 ’ S0 electronic transition as well as different fr...

up engineered T cells as a delivery platform for therapeutics. specific, opening − involved in growth control or transformation. Thus, the safety of retroviral vectors may be cell type evidence of integration-induced immortalization, with no observable enrichment of integration sites near genes of engraftment, and did not require host immunosuppression before transplant. Moreover, the authors f...

Motivation: Our goal is to develop a screening platform for quantitative profiling of colony organizations in 3D cell culture models. The 3D cell culture models, which are also imaged in 3D, are functional assays that mimic the in vivo characteristics of the tissue architecture more faithfully than the 2D cultures. However, they also introduce significant computational challenges, with the main...