A metal extraction system using fluorous solvents has been developed. Perfluorinated beta-diketone, 1,1,1,5,5,6,6,6-octafluoro-2,4-hexanedione (C(6)F(8)betaDK) dissolves in the fluorous solvent FC-72 and can extract transition metal ions from water into FC-72. The extraction efficiency in the FC-72 system is comparable to that of chloroform. By using the immiscibility of FC-72 with conventional...

The study was conducted to evaluate the prevalence of abnormal levels of several serum tumour markers in an institutionalized elderly population. Serum tumour markers assay of carcinoembryonic antigen (CEA), the carbohydrate antigens CA 19-9, CA 72-4 and CA 15-3 (Enzymun-test, Boehringer Mannheim GmbH Diagnostic), alpha-fetoprotein (AFP) and prostate specific antigen (PSA) (Abbot Diagnostic Div...

BACKGROUND Compared with FISH and qRT-PCR analyses, immunohistochemistry (IHC) is the preferred screening test in most pathology practices for ALK-rearrangement detection. With 100% sensitivity and 98% specificity, the VENTANA ALK (D5F3) IHC assay has been approved in the EU and some Asian countries for ALK-rearrangement detection. However, an automated Ventana IHC platform is not available in ...

Antibody-directed enzyme prodrug therapy (ADEPT) using anti-TAG-72 antibody and geldanamycin (GA) prodrug were validated in vitro. To understand the complexity and to explore optimal therapeutic regimens for ADEPT in vivo, a physiologically based pharmacokinetic model (PBPK) is applied to analyze each anatomical component/organ. The baseline model predicts that active drug tumor/plasma exposure...

A high power electronic chip was simulated experimentally to investigate upper cooling capabilities using a variety of pool boiling enhancement techniques. Parametric effects of system pressure, subcooling, surface augmentation, and choice of coolant on boiling heat transfer from a vertical 12.7'x 12.7 mm flat surface were examined. The two fluorocarbon coolants tested, FC-72 and FC-87, resulte...

backgrounds and aims: p53 gene is regarded important in pathogenesis of different cancers. therefore, this study aimed to investigate the frequency of p53 gene codon 72 arg/pro polymorphism in women suffering from breast cancer. materials and methods: a total of 90 patients with breast cancer and 83 matched healthy control women participated in this case-control study. genomic dna was extracted...

Our paper investigates the unexplored impact of education on inflation and of this relationship on economic growth. By using a sample of 102 countries observed on non-overlapping five-year data spells over the period 1963-2001, we find that average schooling years of the working population have a significant negative impact on inflation rates after controlling for the effects of the stance of d...

We discuss the effects of anticipated and experienced regret on decision making under uncertainty. In previous research, using the standard, context-free, gamble paradigm, we found that decision makers anticipate the regret they can experience as a result of post-decisional feedback on forgone outcomes (Zeelenberg, Beattie, van der Pligt, & de Vries, 1996). In the present research we move away ...

We examined how the distribution of information among team members and accountability pressures affected the quality of negotiated settlements reached among teams of friends negotiating against teams of strangers. The main conclusions of the experiment may be summarized by the following findings: (1) Teams of strangers reaped a greater share of the joint profit than did teams of friends when te...

We determined the temperature-induced synthesis of the 72-kD heat-shock protein (hsp72) in hearts of normotensive and spontaneously hypertensive rats (SHR) subjected to whole-body hyperthermia (42.0 +/- 0.5 degrees C for 15 minutes). The animals were studied at three different ages: young (2 months), adult (6 months), and old (18 months). The hsp72 was determined by Western blot analysis using ...