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Patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) have an increased risk of hyperkalaemia. Finerenone, a novel, selective, nonsteroidal, mineralocorticoid receptor antagonist, reduced the incidence cardiovascular events in patients CKD T2D FIDELIO-DKD trial. This post hoc analysis describes predictors hyperkalaemia FIDELIO-DKD. was phase III, multicentre, double-blind trial t...

Abstract Aim The risks associated with Type 2 Diabetes (T2DM) and obesity are increasingly becoming relevant across the world. This review aims to compare clinical outcomes of Bariatric surgery versus medical therapy in management obese patients diabetes. Method A systematic, electronic search was performed according PRISMA guidelines identify articles that compared procedures for diabetic pati...

The c-fms gene encodes the receptor for the macrophage-colony stimulating factor (M-CSF) which promotes the proliferation and survival of cells of the monocytic lineage (1). A cDNA library was constructed from a murine myeloblastic leukemic cell line, BMC-4, in which the c-fms gene was overexpressed (2). Eleven independent full-length cDNAs were isolated after screening with a probe encompassin...

BACKGROUND Deworming is recommended by the WHO in girls and pregnant and lactating women to reduce anaemia in areas where hookworm and anaemia are common. There is conflicting evidence on the harm and the benefits of intestinal geohelminth infections on the incidence and severity of malaria, and consequently on the risks and benefits of deworming in malaria affected populations. We examined the...

We investigated the role that prostaglandins (PGs) and EP receptors play in facilitating the gastroprotective action of capsaicin against HCl/ethanol in rats and mice. Male Sprague-Dawley rats and C57BL/6 mice were used after 18 h of fasting. The animals were given HCl/ethanol (60% in 150 mM HCl) p.o. and killed 1 h later. Capsaicin or various EP agonists were given p.o. 30 min or i.v. 10 min b...

The introgression lines (ILs) from cv. M82 (Solanum lycopersicum) × LA0716 (S. pennellii) have been proven to be exceptionally useful for genetic analysis and gene cloning. The introgressions were originally defined by RFLP markers at their development. The objectives of this study are to develop polymorphic SSR markers, and to re-define the DNA introgression from LA0716 in the ILs. Tomato sequ...

 Let $R$ be a ring‎, ‎and let $n‎, ‎d$ be non-negative integers‎. ‎A right $R$-module $M$ is called $(n‎, ‎d)$-projective if $Ext^{d+1}_R(M‎, ‎A)=0$ for every $n$-copresented right $R$-module $A$‎. ‎$R$ is called right $n$-cocoherent if every $n$-copresented right $R$-module is $(n+1)$-coprese-nted‎, ‎it is called a right co-$(n,d)$-ring if every right $R$-module is $(n‎, ‎d)$-projective‎. ‎$R$...

Tonsils of 829 fattening pigs originating from Belgium (n = 201), Italy (n = 428), and Spain (n = 200) were collected between 2005 and 2007 to study the prevalence of enteropathogenic Yersinia in slaughter pigs. Isolation of Yersinia enterocolitica and Yersinia pseudotuberculosis was done by selective enrichment and by cold enrichment for 7 and 14 days. Pathogenic Y. enterocolitica and Y. pseud...