BACKGROUND Recent studies have suggested that several genes that mediate mercury metabolism are polymorphic in humans. OBJECTIVE We hypothesized that single-nucleotide polymorphisms (SNPs) in metallothionein (MT) genes may underlie interindividual differences in mercury biomarker levels. We studied the potential modifying effects of MT SNPs on mercury exposure-biomarker relationships. METHO...

It has been reported that timiperone, a new butyrophenone, 4'-fluoro-4-[4-(2thioxo -1-benzimidazolynyl) piperidino] butyrophenone, possesses potent antipsychotic activity (Yamasaki et al. 1977; Sato et al. 1978). Tachizawa and co-workers (1979), using a 3 H -spiroperidol binding assay, showed that timiperone inhibited specific 3 H spiroperidol binding in vitro at low concentrations similarly to...

Hole-transport materials (HTMs) play an important role as hole scavenger materials in the most efficient perovskite solar cells (PSCs). Here, for the first time, two Ag-based metal organic complexes (HA1 and HA2) are employed as a new class of dopant-free hole-transport material for application in PSCs. These HTMs show excellent conductivity and hole-transport mobility. Consequently, the device...

H. Piperidine Analogues of Phenyltropanes 967 III. Cocaine Analogues 969 A. Stereoisomers of Cocaine 970 B. Phenyl Ring Substituted Cocaines 970 C. 2â-Substituted Cocaines 973 1. 2â-Substituted Cocaines 973 2. 2â-Substituted 4′-Iodococaines 977 D. N-Modified Cocaines 978 E. 3â-Carbamoyl Analogues of Cocaine 981 F. 3â-Alkylphenyltropanes 982 G. 6/7-Substituted Cocaine and Pseudococaine 982 H. 6-...

In the present study, we examined the effects of extremely low-frequency (ELF) electromagnetic fields on morphine-induced conditioned place preferences in rats. During the conditioning phase (12 days), three groups of rats were placed in a sensory cue-defined environment paired with morphine (10mg/kg, i.p.) following exposure to either 20 Hz (1.80 mT) or 50 Hz (2.20 mT) or sham electromagnetic ...

Low iron availability enhances hypoxic pulmonary vasoconstriction (HPV). Considering that reduced serum iron is caused by increased erythropoiesis, insufficient reabsorption, or elevated hepcidin levels, one might speculate that exaggerated HPV in high-altitude pulmonary edema (HAPE) is related to low serum iron. To test this notion we measured serum iron and hepcidin in blood samples obtained ...

The structural behavior of a chromate aluminate sodalite, Ca8[Al12O24](CrO4)2, at room pressure and on heating from 463 to 982°C was determined by using in situ synchrotron X-ray powder-diffraction data [ = 0.91997(4) Å] and Rietveld refinements. The sample was heated at a rate of about 9.5°C/min., and X-ray traces were collected at intervals of about 17°C. The structure at 463°C is a modulated...

Introdouction: Cone Beam Computed Tomography (CBCT) is a relatively new three-dimensional imaging technology, which has been widely used in dental and maxillofacial imaging. Materials and methods: CBCT scans of 506 maxillary sinuses of 253 individuals (39.9% male and 60.1% female) were evaluated retrospectively for assessing the relationship between sinus mucosal thickening (MT) and dental a...

The purpose of this study was to examine whether intracellular metallothionein (MT) protects against acetaminophen hepatotoxicity. MT-I/II knockout (MT-null) and control mice were given acetaminophen (150-500 mg/kg i.p.), and liver injury was assessed 24 h later. MT-null mice were more susceptible than controls to acetaminophen-induced lethality and hepatotoxicity, as evidenced by elevated seru...