To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with 99mTc-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion ...

A method has been developed and established for residue determination of benazolin-ethyl in soil and rape seed samples by gas chromatography with electron capture detection (GC-ECD). Limits of quantification of the method are 0.005 mg/kg for both soil and rape seed, which are sufficiently below the maximum residue limit, and the limit of detection is 0.0023 ng. The average recoveries of the ana...

99mTc-TRODAT-1 ([2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato(3-)-N2,N2 ,S2,S2 ]oxo-[1R-(exo-exo)]) is a potential agent for dopamine transporter (DAT) SPECT, whereas 6-18F-fluoro-L-dopa (18F-FDOPA) PET has been used for the quantitative assessment of presynaptic nigrostriatal dopaminergic function. The current study i...

The title compound, [Cu(2)(C(14)H(12)ClN(2)O)(2)Cl(2)], is a copper(II) dimer where the metal centres are bridged by O atoms from a 5-chloro-salicylaldehyde group. The coordination geometry of each copper(II) centre is distorted square-pyramidal, with two N atoms from a 2-ethyl-amino-pyridine group and two O atoms from a 5-chloro-salicylaldehyde group occupying the basal positions, and with a C...

The structure of ethyl 2-amino-4-tert-butyl-1,3-thiazole-5carboxylate, C10H16N2O2S, (I), and the structure of the 1:1 adduct 6-methylimidazo[2,1-b]thiazole±2-amino-1,3-thiazole (1/1), C6H6N2S C3H4N2S, (II), have been determined. The molecules in (I) associate via a hydrogen-bonded R2(8) dimer consisting of NÐH N interactions, with the hydrogenbonding array additionally involving NÐH O interacti...

In the title compound, C(7)H(9)FN(2)O(2), the meth-oxy and ethyl groups form dihedral angles of 1.4 (2) and 73.5 (3)°, respectively, with the mean plane of the pyrimidine ring. In the crystal structure, two mol-ecules are linked by a pair of N-H⋯O hydrogen bonds, forming a centrosymmetric dimer.