introduction: neurotensin (nt) is a tridecapeptide that binds specifically to neurotensin receptors. several forms of cancer, including small cell lung cancer, colon, pancreatic and prostate carcinomas especially exocrine pancreatic carcinomas express receptors for neurotensin peptide. radiolabeled neurotensin derivatives with a high affinity for these receptors might be used for scintigraphy. ...

As major histocompatibility complexes in humans, the human leukocyte antigens (HLAs) have important functions to present antigen peptides onto T-cell receptors for immunological recognition and responses. Interpreting and predicting HLA-peptide binding are important to study T-cell epitopes, immune reactions, and the mechanisms of adverse drug reactions. We review different types of machine lea...

Molecular chaperones of the 70-kilodalton heat shock protein (Hsp70) class bind to partially unfolded polypeptide substrates and participate in a wide variety of cellular processes. Differences in peptide-binding specificity among Hsp70s have led to the hypothesis that peptide binding determines specific Hsp70 functions. Protein domains were identified that were required for two separate functi...

The taste presentation and receptor perception mechanism of the salty peptide Stropharia rugosoannulata were predicted verified using omics molecular interaction techniques. combination aspartic acid (D) glutamic (E), or fragments composed arginine (R), constitute characteristic structural basis peptides S. rugosoannulata. intensity positively correlates with its concentration...

Protein–protein interaction (PPI) is one of the key regulatory features driving biomolecular processes and hence targeted for designing therapeutics against diseases. Small peptides are a new emerging class owing to their high specificity low toxicity. For achieving efficient targeting PPI, amino acid side chains often stapled together, resulting in rigidification these peptides. Exploring scop...

OBJECTIVES We carried out identification of a small peptide binding to human hepatocellular carcinoma (HCC) cells with the aim of applying the peptide for future HCC-targeted therapy or imaging. METHODS The biopanning technique using phage peptide display libraries was performed on HCC cells in vitro, and a phage clone expressing the HCC-binding peptide motif was selected. The binding activit...