A number of polymorphisms of the platelet glycoprotein (GP) Ib-V-IX and IIb/IIIa complexes have been described, and the PlA polymorphism of GP IIIa has been associated with coronary thrombosis. We determined the levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) and the genotype distributions of PlA and a variable number tandem repeat (VNTR) polymorphism of GP 1b in subjects w...

for all a1 . . . , am ∈ E, all v1, . . . , vm ∈ −→E , and all λ1, . . . , λm ∈ R. Furthermore, for λi = 0, 1 ≤ i ≤ m, we have f̂(v1 +̂ λ1a1, . . . , vm +̂ λmam) = λ1 · · ·λmf(a1 + λ−1 1 v1, . . . , am + λ−1 m vm). Proof . Let us assume that f̂ exists. We first prove by induction on k, 1 ≤ k ≤ m, that f̂(a1, . . . , vi1 , . . . , vik , . . . , am) = fS(vi1 , . . . , vik), for every S ⊆ {1, . . . ,m},...

Let B(n) denote the collection of all set partitions of [n]. Suppose A1,A2 ⊆ B(n) are cross-intersecting i.e. for all A1 ∈ A1 and A2 ∈ A2, we have A1 ∩A2 6= ∅. It is proved that for sufficiently large n,

Let A1,A2 be standard operator algebras on complex Banach spaces X1, X2, respectively. For k ≥ 2, let (i1, . . . , im) be a sequence with terms chosen from {1, . . . , k}, and define the generalized Jordan product T1 ◦ · · · ◦ Tk = Ti1 · · ·Tim + Tim · · ·Ti1 on elements in Ai. This includes the usual Jordan product A1 ◦ A2 = A1A2 + A2A1, and the triple {A1, A2, A3} = A1A2A3 + A3A2A1. Assume th...

B61 (ephrin-A1), a ligand for eph receptor-protein tyrosine kinases, possesses angiogenic and endothelial cell chemoattractant activity. We report the expression profile of ephrin-A1 during mouse embryogenesis (7.25 to 10.5 days post-coitum (dpc)). Ephrin-A1 expression was first detected in the caudal end of the primitive streak and the developing allantois. At mid head fold stage, ephrin-A1 tr...

Gene expression screening showed decreased ephrin-A1 expression in CD4+ T cells of asthma patients. Ephrin-A1 is the ligand of the Eph receptor family of tyrosine kinases, forming the largest family of receptor tyrosine kinases. Their immune regulatory properties are largely unknown. This study demonstrates significantly reduced ephrin-A1 expression in T cells of asthma patients using real time...

The A1-adenosine receptor (A1-AR) is a G protein-coupled receptor that mediates many of the physiological effects of adenosine in the brain, heart, kidney, and adipocytes. Currently, ligand interactions with the A1-AR can be quantified on large cell populations only by using radioligand binding. To increase the resolution of these measurements, we have designed and characterized a previously un...

Physiological concentrations of NaCl inhibit the hydrolysis of von Willebrand factor (VWF) by ADAMTS-13. This effect is because of the specific binding of chloride ions to VWF. Urea-induced unfolding was measured in the presence of NaCl, CH3COONa, and NaClO4 at pH 8.0, 25 degrees C, for multimeric VWF, the recombinant A1-A2-A3 VWF domains, and the A1 domain. Chloride stabilizes the folded confo...

Activation of factor VIII by factor Xa is followed by proteolytic inactivation resulting from cleavage within the A1 subunit (residues 1-372) of factor VIIIa. Factor Xa attacks two sites in A1, Arg(336), which precedes the highly acidic C-terminal region, and a recently identified site at Lys(36). By using isolated A1 subunit as substrate for proteolysis, production of the terminal fragment, A1...

Purpose Fibrosis in peripheral airways is responsible for airflow limitation in chronic obstructive pulmonary disease (COPD). Annexin A1 modulates several key biological events during inflammation. However, little is known about its role in airway fibrosis in COPD. We investigated whether levels of Annexin A1 were upregulated in patients with COPD, and whether it promoted airway fibrosis. Met...