While the factorization assumption works well for many two-body nonleptonic B meson decay modes, the recent measurement of B̄ → D(∗)0M0 with M = π, ρ and ω shows large deviation from this assumption. We analyze the B → D(∗)M decays in the perturbative QCD approach based on kT factorization theorem, in which both factorizable and nonfactorizable contributions can be calculated in the same framewo...

Richman, Jeremy G., and John W. Regan. a2-Adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells. Am. J. Physiol. 274 (Cell Physiol. 43): C654–C662, 1998.—Vascular wound healing and such pathologies as atherosclerosis and restenosis are characterized by migration and proliferation of the smooth muscle cells of the media after denudation of t...

Adenosine diphosphate (ADP) is a platelet agonist that causes platelet shape change and aggregation as well as generation of thromboxane A2, another platelet agonist, through its effects on P2Y1, P2Y12, and P2X1 receptors. It is now reported that both 2-propylthio-D-dichloromethylene adenosine 5 -triphosphate (AR-C67085), a P2Y12 receptor–selective antagonist, and adenosine-2 -phosphate-5 -phos...

Synthesis of progeny DNA genomes in cells infected by human subgroup C adenoviruses leads to several changes in viral gene expression. These changes include transcription from previously silent, late promoters, such as the IV(a2) promoter, and a large increase in the efficiency of major-late (ML) transcription. Some of these changes appear to take place sequentially, because the product of the ...

BACKGROUND As a potent CD8(+) T cell activator, peptide vaccine has found its way in vaccine development against intracellular infections and cancer, but not against leishmaniasis. The first step toward a peptide vaccine is epitope mapping of different proteins according to the most frequent HLA types in a population. METHODS AND FINDINGS Six Leishmania (L.) major-related candidate antigens (...

RATIONALE The balance between vascular prostacyclin, which is antithrombotic, and platelet thromboxane A2, which is prothrombotic, is fundamental to cardiovascular health. Prostacyclin and thromboxane A2 are formed after the concerted actions of cPLA2α (cytosolic phospholipase A2) and COX (cyclooxygenase). Urinary 2,3-dinor-6-keto-PGF1α (PGI-M) and 11-dehydro-TXB2 (TX-M) have been taken as biom...

OBJECTIVES We studied the association of the Pl(A1/A2) polymorphism with coronary thrombosis, myocardial infarction (MI) and sudden cardiac death (SCD) in autopsied victims of sudden death. BACKGROUND Sudden cardiac death is one of the leading symptoms of coronary heart disease in early middle age. Platelet glycoprotein (GP)IIb/IIIa fibrinogen receptors play a key role in coronary thrombosis ...

In patients with atrioventricular (A-V) nodal re-entrant paroxysmal supraventricular tachycardia (PSVT), atrial extrastimulus technique frequently reveals discontinuous A1-A2, H1-H2 curves suggestive of dual A-V nodal pathways. To further test the hypothesis that these curves in fact reflect dual A-V nodal pathways, a ventricular extrastimulus (VS) was coupled either to A2 at a fixed A1-A2 inte...

The existence of non-trivial solutions X to matrix equations of the form F (X,A1,A2, · · · ,As) = G(X,A1,A2, · · · ,As) over the real numbers is investigated. Here F and G denote monomials in the (n × n)-matrix X = (xij) of variables together with (n × n)-matrices A1,A2, · · · ,As for s ≥ 1 and n ≥ 2 such that F and G have different total positive degrees in X. An example with s = 1 is given by...

HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n = 161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was perform...