triple a syndrome (allgrove syndrome) is a rare inherited autosomal recessive disease with a typical triad including adrenocorticotrophic-hormone-resistant glucocorticoid insufficiency, reduced or absent tearing (alacrima) and achalasia and a wide range of symptoms can be detected due to multi organ involvement. this report describes the case of a triple asyndrome, a12 year-old boy with a histo...

BACKGROUND Virtually no reports on the effects of exercise in patients with a small abdominal aortic aneurysm (AAA) exist. METHODS AND RESULTS We conducted a retrospective cohort study on 1515 patients with a small AAA before surgery at 2 high-volume hospitals in Tokyo, Japan, from April 2004 to September 2015. A carefully modified cardiac rehabilitation program without excessive blood pressu...

Background and aims Determine the effect of AMPK activation and inhibition on the development of AAA (abdominal aortic aneurysm). Methods AAA was induced in ApoE-/- mice by Ang II (Angiotensin II)-infusion. AICAR (5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside) was used as AMPK activator and Compound C was used as AMPK inhibitor. We further investigate the effect of metformin, a widely u...

We aimed to evaluate the frequency, clinical profiles and outcomes of abdominal aortic aneurysms (AAA), and their association with coronary artery disease (CAD) in a small country with high cardiovascular burden. Methods. Data were collected for all adult patients who underwent abdominal computed tomography scans at Hamad General Hospital in Qatar between 2004 and 2008. Results. Out of 13,115 s...

We investigated whether any variables in a health-screened population study were associated with later development of large abdominal aortic aneurysms (AAA). Material and methods: Within the Malmö Preventive Study 22 444 men and 10 982 women were investigated between 1974 and 1991. The mean age at the health screening was 43.7 years. Results: After a median follow-up of 21 years, 126 men and si...

OBJECTIVE To establish whether UK emergency physicians could reliably perform focused ultrasound of the abdominal aorta in patients with suspected abdominal aortic aneurysm (AAA). METHODS A prospective cohort study was conducted in the emergency department of a tertiary level UK teaching hospital. All patients who underwent an abdominal aortic ultrasound by an emergency physician during a 12 ...

No drug therapy has shown to limit abdominal aortic aneurysm (AAA) growth or rupture, and the understanding of disease biology is incomplete; whereby, one challenge vascular medicine development good animal models therapies for this life-threatening condition. The nuclear receptor NOR-1 (neuron-derived orphan 1) controls biological processes involved in AAA; however, whether it plays a role pat...

The aim of the study was to investigate the functional mechanisms of osteopontin (Opn) and chemokine-like factor 1 (Cklf1) during the development and progression of abdominal aortic aneurysms (AAA) in rats. Healthy adult Sprague-Dawley rats (n=30) were randomly divided into the AAA, control and sham groups (10 rats/group) and experimental rat models of AAA were generated by enzyme perfusion in ...