Masaki Takagi1, 2, Ryojun Takeda3, Hiroko Yagi4, Daisuke Ariyasu5, Ryuji Fukuzawa2, and Tomonobu Hasegawa1 1 Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan 2 Department of Pathology and Laboratory Medicine, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan 3 Department of Medical Genetics, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan 4 Departme...

Amaç: Koroner arter hastalığı (KAH), Amerika Birleşik Devletleri ve diğer gelişmiş ülkelerde ilk ölüm nedeni olan, dünyadaki en yüksek oranına sahip hastalıklardan biridir. Bireylerin yaşam kalitesinin arttırılması açısından koroner hastalığına yatkınlığın olup olmadığının erken zamanda öğrenilebilmesi, önlem alınması veya tedavi şansının oluşturulabilmesi için genetik alt yapısının belirlenmes...

Abstract Background Diagnosis of monogenic diabetes has important clinical implications for treatment and health expenditure. However, its prevalence remains to be specified in many countries, particularly from South Europe, North Africa Middle-East, where non-autoimmune young adults is increasing dramatically. Aims To identify cases Mediterranean countries assess the specificities between coun...

Manifest diabetes, but also conditions of increased insulin resistance such as pregnancy or obesity can lead to islet architecture remodeling. The contributing mechanisms are poorly understood the consequences altered cell arrangement. For quantification different types frequency cell-cell contacts within islets, approaches exist. However, few methods available characterize distribution in a st...

Maturity onset diabetes of the young is a dominantly inherited form monogenic diabetes, diagnosed mainly before age 35 years. Mutations in HNF1A and HNF4A genes are associated with mellitus HNF1A-MODY HNF4A-MODY subtypes, respectively. These two forms MODY characterized by dyslipidemia addition to impaired glucose metabolism due altered function proteins. The aim this study was genetic analysis...