It has been suggested that nitric oxide (NO) stimulates the cyclooxygenase (COX)-dependent mechanisms in the ocular vasculature; however, the importance of the pathway in regulating retinal circulation in vivo remains to be elucidated. Therefore, we investigated the role of COX-dependent mechanisms in NO-induced vasodilation of retinal blood vessels in thiobutabarbital-anesthetized rats with an...

THERE is convincing clinical evidence that retrolental fibroplasia is the result of a disturbance of the oxygen conditions to which an infant is normally exposed. Direct experimental evidence of this was supplied by Ashton and others (1953), the anatomical studies of Michaelson (1948) and the physiological studies of Campbell (1951) having previously suggested the significance of the role of ox...

Retinal blood vessels can give information about abnormalities or disease by examining its pathological changes. One abnormality is diabetic retinopathy, characterized by a disorder of retinal blood vessels resulting from diabetes mellitus. Currently, diabetic retinopathy is one of the major causes of human vision abnormalities and blindness. Hence, early detection can lead to proper treatment,...

Angiogenesis, the growth of new vessels from pre-existing blood vessels, requires complex signaling pathways and a high degree of spatial and temporal coordination among various cell types, multiple proand anti-angiogenic factors, and their corresponding receptors. Although the targeted disruption of many of these factors leads to embryonic lethal defects in vascular development, the precise ac...

Patients with retinal problems are increasingly examined with morphologic measurements such as optic coherence imaging (OCT), which is quick and easy to administer. This might give the impression that more time-consuming functional assessments, such as electrophysiological examinations, are unnecessary. However, these tests measure different things—as Dhamdhere et al. showed in patients with di...

This paper presents a method for the extraction of blood vessels from fundus images. The proposed method is an unsupervised learning method which can automatically segment retinal blood vessels based on an adaptive random sampling algorithm. This algorithm consists in taking an adequate number of random samples in fundus images, and all the samples are contracted to the position of the blood ve...

The production of cortisol increases in acute stress but the effects of chronic stress on plasma cortisol are still controversial. Stress on the other hand plays a role in coronary artery disease (CAD) and carotid atherosclerosis. Since there is no data about plasma cortisol and atherosclerosis of the retinal arteries, the purpose of this study was to explore the relationship between plasma cor...

A 38-year-old man who died from systemic Behçet's disease had previously suffered from severe, recurrent bilateral retinal vasculitis, and anterior uveitis for 10 years. Immunopathological examination of the eyes postmortem revealed marked hyaline thickening of the retinal and optic nerve vessels. The vessels had an intramural and perivascular infiltrate of T lymphocytes which stained positivel...